{"id":"W1981875981","doi":"10.1016/s0264-410x(02)00303-1","title":"Construction and immunogenicity of a codon-optimized Entamoeba histolytica Gal-lectin-based DNA vaccine","year":2002,"lang":"en","type":"article","venue":"Vaccine","topic":"Amoebic Infections and Treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Entamoeba histolytica; Immunogenicity; Lectin; DNA vaccination; Biology; Virology; Recombinant DNA; Immune system; Protein subunit; Microbiology; Antibody; C-type lectin; Molecular biology; Immunology; Gene; Immunization; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001015453,0.0001998488,0.0004860545,0.0002108823,0.0001197809,0.000008112932,0.00003955586,0.0001026692,0.002432432],"category_scores_gemma":[0.00009867551,0.0001661355,0.0001265349,0.0003106222,0.00002518021,0.0000565952,0.00002428464,0.0001452465,0.00003474955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001336336,"about_ca_system_score_gemma":0.00003646181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002043548,"about_ca_topic_score_gemma":0.00001494614,"domain_scores_codex":[0.9989164,0.00003897047,0.000401724,0.0002684937,0.0001542605,0.0002201077],"domain_scores_gemma":[0.9991294,0.00009220875,0.0001735846,0.0003360676,0.0001488083,0.0001199503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007205307,0.005664479,0.7925021,0.0006851599,0.002487955,0.0002468847,0.0005734161,0.000113901,0.11893,0.0007640176,0.01315084,0.05767595],"study_design_scores_gemma":[0.1940187,0.00967756,0.4304914,0.001009903,0.006352386,0.005278228,0.000450591,0.03594071,0.2825014,0.0004149694,0.03207958,0.001784635],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928841,0.0009893512,0.001243756,0.0008773658,0.0002596243,0.0005067041,0.00001275159,0.00009885292,0.003127503],"genre_scores_gemma":[0.99302,0.0001912967,0.005334067,0.0001297459,0.00006694288,0.00002154046,0.00002676623,0.00002478301,0.001184832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3620107,"threshold_uncertainty_score":0.9984795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140672937201569,"score_gpt":0.2295834723910919,"score_spread":0.2181767430190762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}