{"id":"W1981915247","doi":"10.1021/jm3006492","title":"Synthesis, Biological Evaluation, and Structure–Activity Relationships of Novel Substituted <i>N</i>-Phenyl Ureidobenzenesulfonate Derivatives Blocking Cell Cycle Progression in S-Phase and Inducing DNA Double-Strand Breaks","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Cisplatin; Combretastatin; Cell cycle; Fibrosarcoma; DNA; Chorioallantoic membrane; Cell culture; DNA synthesis; Stereochemistry; DNA damage; Cell; Biochemistry; Cell biology; In vitro; Chemotherapy; Biology; Genetics; Tubulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002077661,0.000175424,0.0005444291,0.00008997028,0.00008857932,0.00001239845,0.00006884484,0.0001724553,0.00006346215],"category_scores_gemma":[0.001033821,0.000114051,0.00005125322,0.0001432601,0.0001990382,0.0002014793,0.00003434929,0.0005307238,5.398111e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004743146,"about_ca_system_score_gemma":0.0001263669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001198264,"about_ca_topic_score_gemma":0.000001560547,"domain_scores_codex":[0.9984129,0.0001279864,0.0005952736,0.000158639,0.0005073181,0.0001978971],"domain_scores_gemma":[0.9984825,0.0003966166,0.0005762192,0.0001170769,0.0002238145,0.0002038238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001437984,0.0003578537,0.05345551,0.0003641552,0.00004543746,0.000005510723,0.0006391035,0.00001087179,0.9384542,0.000005655796,0.000003272057,0.005220491],"study_design_scores_gemma":[0.004905686,0.0001263247,0.1214249,0.001213646,0.000237476,0.0005931847,0.0005137496,0.0004254364,0.8703598,0.00005155107,0.00003276285,0.0001154882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921258,0.007040881,0.000119164,0.0002059892,0.00005456322,0.0001826176,0.000007703255,0.000004946141,0.0002583009],"genre_scores_gemma":[0.9982385,0.0001651621,0.001352475,0.00001236417,0.0002101719,0.000004055277,0.000004011193,0.00001044717,0.000002816857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0680944,"threshold_uncertainty_score":0.4650865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1100392274821086,"score_gpt":0.3459490710458548,"score_spread":0.2359098435637462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}