{"id":"W1981915247","doi":"10.1021/jm3006492","title":"Synthesis, Biological Evaluation, and Structure–Activity Relationships of Novel Substituted <i>N</i>-Phenyl Ureidobenzenesulfonate Derivatives Blocking Cell Cycle Progression in S-Phase and Inducing DNA Double-Strand Breaks","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Cisplatin; Combretastatin; Cell cycle; Fibrosarcoma; DNA; Chorioallantoic membrane; Cell culture; DNA synthesis; Stereochemistry; DNA damage; Cell; Biochemistry; Cell biology; In vitro; Chemotherapy; Biology; Genetics; Tubulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007963905,0.0002004017,0.000144437,0.00008360272,0.00007127084,0.0001117929,0.0001398241,0.0001059458,0.0007750397],"category_scores_gemma":[0.000064167,0.00007734278,0.0001030634,0.00009394125,0.0001157921,0.00008447197,0.00006336084,0.0001458825,0.0001634376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001708581,"about_ca_system_score_gemma":0.0001902088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006323854,"about_ca_topic_score_gemma":0.001656352,"domain_scores_codex":[0.9999682,0.0000079811,0.000003181027,0.000005886168,0.00000806842,0.000006594459],"domain_scores_gemma":[0.9999453,0.000005861689,0.00001985489,0.000004272053,0.000008782267,0.00001579981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001847966,0.00006642091,0.0001969875,0.00004887744,0.000004927007,0.00002625729,0.000008567117,0.0002343362,0.9957486,0.00006648833,0.00003630881,0.003377371],"study_design_scores_gemma":[0.00007562296,0.002523963,0.002210291,0.00000353213,0.00002450246,0.0001821923,0.00001141393,0.0005058618,0.9919968,0.00001291194,0.002447985,0.000004953856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954414,0.001499795,0.001286888,0.0000329201,0.00000787303,0.00004217633,0.000150387,0.00003749231,0.001501007],"genre_scores_gemma":[0.9951537,0.001415821,0.001928702,0.00002171726,0.000005822262,0.00001821006,0.0002758072,0.000005033772,0.001175142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007750397,"threshold_uncertainty_score":0.002592742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1100392274821086,"score_gpt":0.3459490710458548,"score_spread":0.2359098435637462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}