{"id":"W1981945499","doi":"10.1097/nen.0b013e31823cc7a6","title":"Butyrylcholinesterase Is Associated With β-Amyloid Plaques in the Transgenic APP<sub>SWE</sub>/PSEN1dE9 Mouse Model of Alzheimer Disease","year":2011,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Saint Vincent University; Dalhousie University","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Butyrylcholinesterase; Thioflavin; Immunostaining; Pathology; Alzheimer's disease; Genetically modified mouse; Acetylcholinesterase; Senile plaques; Amyloid (mycology); Immunohistochemistry; Biology; Transgene; Aché; Medicine; Disease; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003228767,0.00141348,0.0008658461,0.001726318,0.0005814559,0.0006764779,0.0003503341,0.001263405,0.001970478],"category_scores_gemma":[0.0002119138,0.000694942,0.0007466403,0.0006115767,0.0005390288,0.000722752,0.0004385494,0.001758265,0.0009000259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003941185,"about_ca_system_score_gemma":0.0002441844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001093024,"about_ca_topic_score_gemma":0.001546071,"domain_scores_codex":[0.999605,0.00003563345,0.00006256292,0.000119706,0.0001142556,0.00006284654],"domain_scores_gemma":[0.9995595,0.00003176515,0.0001691306,0.00003959678,0.00005099833,0.0001491215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003515213,0.0001526773,0.0003983114,0.00005404779,0.00002310922,0.0004692645,0.00006179701,0.00003015779,0.9975538,0.00009664232,0.00006225634,0.0007464605],"study_design_scores_gemma":[0.0003079181,0.002604659,0.07244404,0.00008801815,0.0002871766,0.008511615,0.0002262781,0.00203858,0.9060922,0.0009307024,0.006407358,0.00006130785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918704,0.002270161,0.002744841,0.0002784375,0.00007465554,0.00008632504,0.0009205348,0.0001964073,0.001558299],"genre_scores_gemma":[0.9759511,0.00404887,0.005912772,0.000258554,0.00007078768,0.000263238,0.002367586,0.0001876486,0.01093962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001970478,"threshold_uncertainty_score":0.006591856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05557986016765855,"score_gpt":0.2884073281358777,"score_spread":0.2328274679682191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}