{"id":"W1981947870","doi":"10.1002/1097-4547(20001015)62:2<286::aid-jnr13>3.0.co;2-0","title":"Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: An in vitro model for the study of cell death mechanisms in Wernicke's encephalopathy","year":2000,"lang":"en","type":"article","venue":"Journal of Neuroscience Research","topic":"Alcoholism and Thiamine Deficiency","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Saint-Luc","funders":"","keywords":"Thiamine; Thiamine deficiency; Encephalopathy; In vitro; Metabolic acidosis; Granule (geology); Neuroscience; Wernicke Encephalopathy; Acidosis; Biology; Chemistry; Medicine; Biochemistry; Endocrinology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002170472,0.00081819,0.0006617977,0.0003765761,0.0002615589,0.0004317815,0.0004237064,0.0005926489,0.001175253],"category_scores_gemma":[0.0001275996,0.0002333651,0.0003573963,0.0003844925,0.0004403155,0.0002907318,0.0003989985,0.0006869811,0.0006025131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004079459,"about_ca_system_score_gemma":0.0002086154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001829349,"about_ca_topic_score_gemma":0.002919164,"domain_scores_codex":[0.9997489,0.00005609997,0.00004967443,0.00005517699,0.00004060004,0.00004945124],"domain_scores_gemma":[0.9998465,0.00003760188,0.0000368995,0.00003686432,0.00001070321,0.00003134189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005602813,0.0001294325,0.0006847705,0.00007784059,0.00002043255,0.0007846198,0.00006273222,0.000131111,0.9965873,0.0001001887,0.00003316292,0.0008282185],"study_design_scores_gemma":[0.00009543536,0.001822881,0.009448502,0.00001595326,0.00007587452,0.001621353,0.0001182869,0.001041077,0.9839339,0.00007479549,0.001740794,0.00001111579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944522,0.002175327,0.001661882,0.00007820684,0.00005041925,0.0000574254,0.0003600188,0.00003811599,0.001126426],"genre_scores_gemma":[0.9935319,0.001984797,0.001615136,0.00002829549,0.00001529076,0.00009637348,0.0006653433,0.00001762408,0.002045201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829349,"threshold_uncertainty_score":0.003931642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07133912223708949,"score_gpt":0.3478614902710345,"score_spread":0.276522368033945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}