{"id":"W1981952398","doi":"10.3390/md11103661","title":"Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin","year":2013,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Institutes of Health; Instituto de Salud Carlos III; Junta de Castilla y León","keywords":"Camptothecin; Leishmania donovani; Topoisomerase; Leishmania; Mechanism (biology); Fatty acid; Biochemistry; Chemistry; Stereochemistry; Biology; Leishmaniasis; Enzyme; Visceral leishmaniasis; Genetics; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644824,0.0003537586,0.0005111472,0.00006374803,0.00006581817,0.00003373067,0.0003766023,0.0001729541,0.000635264],"category_scores_gemma":[0.0000190082,0.0002271319,0.000180287,0.0001172343,0.0001117457,0.00001004535,0.0005234602,0.000162027,0.000005442291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003364759,"about_ca_system_score_gemma":0.00004089147,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01253254,"about_ca_topic_score_gemma":0.001136563,"domain_scores_codex":[0.9984832,0.0001536051,0.0002977201,0.0004958996,0.0002796213,0.0002899901],"domain_scores_gemma":[0.9986174,0.0001300693,0.0003195365,0.0007322839,0.0001102883,0.00009046038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004227231,0.0001692012,0.01162774,0.00002709767,0.0006990216,0.000001890244,0.0001907632,0.000003179522,0.9438252,0.0002638474,0.00003147765,0.04273784],"study_design_scores_gemma":[0.001127173,0.0003205075,0.05377381,0.00004434121,0.0002052908,0.000002567567,0.0002339926,0.00007084225,0.9399864,0.00370302,0.0002654321,0.0002665914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948192,0.0001126065,0.003388766,0.0002051714,0.0001088129,0.0005925024,0.0002380691,0.00001630554,0.0005185413],"genre_scores_gemma":[0.9977267,0.0002193501,0.001140546,0.0002391831,0.00007500304,0.0001419847,0.0002562566,0.00005362135,0.0001473549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04247125,"threshold_uncertainty_score":0.9940431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007944123220935337,"score_gpt":0.2061341486272436,"score_spread":0.1981900254063083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}