{"id":"W1981952398","doi":"10.3390/md11103661","title":"Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin","year":2013,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Institutes of Health; Instituto de Salud Carlos III; Junta de Castilla y León","keywords":"Camptothecin; Leishmania donovani; Topoisomerase; Leishmania; Mechanism (biology); Fatty acid; Biochemistry; Chemistry; Stereochemistry; Biology; Leishmaniasis; Enzyme; Visceral leishmaniasis; Genetics; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008678262,0.0005186264,0.0002417267,0.0002027562,0.0001209622,0.0001877729,0.0001991888,0.0002180023,0.0009127846],"category_scores_gemma":[0.0001003663,0.000124474,0.0002583993,0.0002054429,0.0001378448,0.0001794748,0.0001990136,0.000416664,0.0003635531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002117745,"about_ca_system_score_gemma":0.0003156652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005269651,"about_ca_topic_score_gemma":0.00106648,"domain_scores_codex":[0.9999446,0.000009262125,0.000008019188,0.00001096553,0.00001349875,0.00001374241],"domain_scores_gemma":[0.9999187,0.000007926192,0.00002772265,0.000009942602,0.00001509476,0.00002057106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006944434,0.000009123955,0.00007080644,0.00005537483,0.000005413354,0.00006631199,0.000008815295,0.00008251251,0.9982474,0.00005600129,0.00001153321,0.001317281],"study_design_scores_gemma":[0.00001914343,0.0004353557,0.0008830743,0.00001134561,0.00002975629,0.0001354624,0.00002303736,0.000132455,0.9943446,0.00003330417,0.003947031,0.000005334764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820732,0.004065803,0.007666492,0.0001523384,0.00007863667,0.0001442925,0.001000201,0.00009511373,0.004723876],"genre_scores_gemma":[0.9832799,0.003078881,0.008280149,0.0000979706,0.000021802,0.00008787658,0.001521124,0.00003077573,0.003601486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009127846,"threshold_uncertainty_score":0.003053546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007944123220935337,"score_gpt":0.2061341486272436,"score_spread":0.1981900254063083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}