{"id":"W1981955743","doi":"10.1158/1538-7445.am2013-3972","title":"Abstract 3972: Carpet bombing with CARs: Influence of dose, timing, lymphodepletion and costimulatory domain on efficacy of mRNA engineered anti-CD19 Chimeric Antigen Receptor T cells in preclinical xenograft models.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chimeric antigen receptor; CD28; Electroporation; Cancer research; Ex vivo; Transduction (biophysics); Genetic enhancement; CD19; Viral vector; T cell; Antigen; Medicine; Immunology; Biology; In vivo; Immune system; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004135274,0.0005272646,0.0004124011,0.0003024972,0.000133121,0.0002798556,0.000292152,0.0004407161,0.001687926],"category_scores_gemma":[0.0002093129,0.000175343,0.0002997538,0.0002311917,0.0002236999,0.0002707222,0.0001271947,0.0007500881,0.0004072645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003491509,"about_ca_system_score_gemma":0.000308326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001579533,"about_ca_topic_score_gemma":0.001479874,"domain_scores_codex":[0.9997464,0.00006543297,0.00002095566,0.00003452521,0.00006115325,0.00007150283],"domain_scores_gemma":[0.9997228,0.00009451184,0.00004983579,0.00003048144,0.00002565436,0.00007674538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001778148,0.0007632956,0.0002377831,0.0000414755,0.00001229445,0.00003295464,0.00003707976,0.0004501198,0.9932025,0.00006074469,0.0002152681,0.003168377],"study_design_scores_gemma":[0.0000750958,0.006335923,0.001298926,0.000003552161,0.00002339693,0.00004635612,0.00001139571,0.0008847364,0.9906732,0.000009515328,0.0006327248,0.000005090857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973283,0.0006514215,0.0006012427,0.00004870821,0.00003823001,0.00004530014,0.0003537846,0.00005530143,0.000877601],"genre_scores_gemma":[0.9944259,0.0005287112,0.001465436,0.00004150672,0.00001770544,0.00008518762,0.0008193133,0.00005004055,0.002566271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001687926,"threshold_uncertainty_score":0.005646646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07944169261502196,"score_gpt":0.390579464507352,"score_spread":0.3111377718923301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}