{"id":"W1982010291","doi":"10.1007/s11064-007-9333-x","title":"Neuroprotective Effects of Natural Products: Interaction with Intracellular Kinases, Amyloid Peptides and a Possible Role for Transthyretin","year":2007,"lang":"en","type":"article","venue":"Neurochemical Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Neuroprotection; Transthyretin; Resveratrol; Choroid plexus; Biochemistry; Polyphenol; Kinase; Amyloid (mycology); Chemistry; Protein kinase C; Catechin; Phosphorylation; Epigallocatechin gallate; Pharmacology; Cell biology; Biology; Neuroscience; Central nervous system; Antioxidant; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002485866,0.0006019705,0.0004321684,0.0002356992,0.000230479,0.000347123,0.0002364084,0.000383642,0.001487115],"category_scores_gemma":[0.0001991486,0.000137554,0.0004039882,0.0001541379,0.0004326296,0.0007094473,0.0001865133,0.0004460357,0.0001627544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002571645,"about_ca_system_score_gemma":0.0001686286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003929615,"about_ca_topic_score_gemma":0.0005211267,"domain_scores_codex":[0.9999239,0.00002792803,0.000005210177,0.00001056379,0.000009712925,0.00002263459],"domain_scores_gemma":[0.9999011,0.00002919022,0.00002725715,0.00001211417,0.00001416693,0.00001619632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004410543,0.0001852113,0.001117916,0.0004745839,0.00007580643,0.001143588,0.000123405,0.0002678102,0.975987,0.001244947,0.0001829621,0.01478618],"study_design_scores_gemma":[0.0002968159,0.003079536,0.02212419,0.00006406006,0.0001928576,0.003025704,0.0002694468,0.0007854632,0.9603376,0.002674135,0.007117109,0.00003296913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9389202,0.0542708,0.002616917,0.0004959883,0.00006575492,0.00003482373,0.0001540492,0.00004023384,0.003401221],"genre_scores_gemma":[0.9841282,0.01220044,0.001585265,0.0001050611,0.00005443534,0.00002634953,0.0001619415,0.000008527739,0.001729896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487115,"threshold_uncertainty_score":0.004974842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02148326109932377,"score_gpt":0.3423465885153674,"score_spread":0.3208633274160436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}