{"id":"W1982010291","doi":"10.1007/s11064-007-9333-x","title":"Neuroprotective Effects of Natural Products: Interaction with Intracellular Kinases, Amyloid Peptides and a Possible Role for Transthyretin","year":2007,"lang":"en","type":"article","venue":"Neurochemical Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Neuroprotection; Transthyretin; Resveratrol; Choroid plexus; Biochemistry; Polyphenol; Kinase; Amyloid (mycology); Chemistry; Protein kinase C; Catechin; Phosphorylation; Epigallocatechin gallate; Pharmacology; Cell biology; Biology; Neuroscience; Central nervous system; Antioxidant; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004358816,0.0001626006,0.0002572884,0.0002366275,0.0001075924,0.00002675679,0.00009428093,0.00007037127,0.0000051831],"category_scores_gemma":[0.001590595,0.000118993,0.00006034761,0.000476014,0.0003785161,0.0001061275,0.00005158643,0.0006935589,0.000004222476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007341682,"about_ca_system_score_gemma":0.0001709035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000558671,"about_ca_topic_score_gemma":0.00000520712,"domain_scores_codex":[0.997844,0.0001059853,0.0001942308,0.0004975171,0.0007590002,0.0005991966],"domain_scores_gemma":[0.9977117,0.0009898724,0.00004172747,0.0002495607,0.000680854,0.0003262797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01249148,0.0007311055,0.001500321,0.0009874821,0.0004510224,0.0003145082,0.0002040288,1.304839e-7,0.9744558,0.00003089448,0.0000754179,0.008757778],"study_design_scores_gemma":[0.002634852,0.003235548,0.009106421,0.0002391077,0.0001022233,0.00009774794,0.0001688496,0.000122874,0.9838945,0.0001657186,0.0001413825,0.00009078179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932498,0.003806314,0.00005898712,0.0004206221,0.00002214075,0.002216465,0.000006875274,0.0000305083,0.0001882791],"genre_scores_gemma":[0.9989475,0.0001118201,0.0005372902,0.00002530471,0.0001054136,0.0001504762,0.00002705928,0.00003649748,0.00005866704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00985663,"threshold_uncertainty_score":0.4852392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02148326109932377,"score_gpt":0.3423465885153674,"score_spread":0.3208633274160436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}