{"id":"W1982013103","doi":"10.1021/ja054550e","title":"Multiple-Site Exchange in Proteins Studied with a Suite of Six NMR Relaxation Dispersion Experiments:  An Application to the Folding of a Fyn SH3 Domain Mutant","year":2005,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Folding (DSP implementation); SH3 domain; Dispersion (optics); Relaxation (psychology); Crystallography; Chemical physics; Physics; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007168583,0.0003577621,0.000506675,0.0003187799,0.0003765397,0.0002591721,0.0003218214,0.0005022477,0.0002394055],"category_scores_gemma":[0.0008154236,0.0001702804,0.0004643823,0.0004279487,0.0004091778,0.0002418571,0.0004341138,0.0008300898,0.00005182045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002613552,"about_ca_system_score_gemma":0.000163995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008222203,"about_ca_topic_score_gemma":0.0008803806,"domain_scores_codex":[0.9998308,0.00003489404,0.00001136205,0.00003542421,0.00007069491,0.00001683166],"domain_scores_gemma":[0.9995382,0.0001265092,0.0001004317,0.000085422,0.00006197897,0.00008749376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002371688,0.0001016336,0.001774416,0.00004215701,0.00002392195,0.0000913995,0.0001046623,0.001907256,0.9906376,0.0001311094,0.00004597153,0.004902746],"study_design_scores_gemma":[0.00004552767,0.000683032,0.01503391,0.00001195814,0.00003018997,0.0007895657,0.00007833148,0.02794114,0.9544636,0.0002600386,0.0006244052,0.00003832714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947318,0.0001654644,0.004820775,0.00003552224,0.000004690888,0.00001307263,0.00006636117,0.00005575407,0.0001066379],"genre_scores_gemma":[0.9799658,0.000313467,0.01912572,0.00002201757,0.000005389723,0.00003251489,0.0002299602,0.00003085096,0.0002742585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008222203,"threshold_uncertainty_score":0.003791213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005728429962307753,"score_gpt":0.252611706658938,"score_spread":0.2468832766966303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}