{"id":"W1982033147","doi":"10.1016/s0022-2836(02)01279-2","title":"Alternate Aggregation Pathways of the Alzheimer β-Amyloid Peptide: Aβ Association Kinetics at Endosomal pH","year":2002,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Chemistry; Endosome; Biophysics; Kinetics; Phase (matter); Fibril; Circular dichroism; Protein aggregation; Amyloid (mycology); Förster resonance energy transfer; Neurodegeneration; Amyloid fibril; Peptide; Crystallography; Fluorescence; Biochemistry; Amyloid β; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008420772,0.0004129827,0.0005092104,0.0003988985,0.0004111938,0.001440345,0.0004653514,0.0006963106,0.00198573],"category_scores_gemma":[0.002841997,0.0005132611,0.000338821,0.0003008604,0.0003287102,0.00290713,0.0006223749,0.001078284,0.0007736425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001084392,"about_ca_system_score_gemma":0.0005177016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007680188,"about_ca_topic_score_gemma":0.0005397062,"domain_scores_codex":[0.9995907,0.00005402279,0.00003918158,0.0001017841,0.0001095323,0.0001047721],"domain_scores_gemma":[0.9989902,0.0003829358,0.0001370532,0.00008696311,0.0002751731,0.0001275135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003891553,0.0002291117,0.002744006,0.0003727009,0.0000660892,0.0003945129,0.000592066,0.001907179,0.9586496,0.01532676,0.001029632,0.01479676],"study_design_scores_gemma":[0.0002891554,0.0006067566,0.01751374,0.00005308274,0.0001089994,0.001410257,0.0003670461,0.0659206,0.8993593,0.0104968,0.003721622,0.0001525711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879512,0.001276102,0.007903017,0.0002650819,0.00004634997,0.00004403474,0.0003349691,0.0001456855,0.002033442],"genre_scores_gemma":[0.9940342,0.001133239,0.002559226,0.00008078649,0.00001818451,0.00005354542,0.0003293363,0.00004360736,0.001747934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00198573,"threshold_uncertainty_score":0.007867813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03073455786757786,"score_gpt":0.2926914728029494,"score_spread":0.2619569149353715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}