{"id":"W1982052181","doi":"10.1124/dmd.108.022483","title":"Disparity in Intestine Disposition between Formed and Preformed Metabolites and Implications: A Theoretical Study","year":2008,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Metabolite; Chemistry; Pharmacokinetics; Area under the curve; Oral administration; Metabolism; Pharmacology; Active metabolite; Enterocyte; Small intestine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009414745,0.0003657181,0.0005920402,0.0002750263,0.0005052098,0.00005435,0.0001430361,0.000181219,0.00004934597],"category_scores_gemma":[0.0001215437,0.0003146262,0.00005705428,0.0003412203,0.0006787298,0.0004171299,0.0002038976,0.0005411568,0.000005186256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002109252,"about_ca_system_score_gemma":0.00003865419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000862615,"about_ca_topic_score_gemma":0.0000304847,"domain_scores_codex":[0.9975334,0.0006112369,0.0005777325,0.0005995772,0.0001888981,0.0004891641],"domain_scores_gemma":[0.9986731,0.0004437128,0.0001446205,0.0002091406,0.00009116548,0.000438287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000743625,0.001593016,0.8406113,0.0001221955,0.0002313575,0.0000465414,0.007984203,0.000009632155,0.02836667,0.05937051,0.00009959377,0.06082132],"study_design_scores_gemma":[0.004005456,0.00006455123,0.9714646,0.00001655221,0.0006091204,0.0001150631,0.0003623258,0.000762806,0.004590557,0.01627749,0.001359207,0.0003722669],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875723,0.00913387,0.0002813333,0.0009310924,0.000185106,0.001139984,0.0002331616,0.00006905721,0.0004540619],"genre_scores_gemma":[0.9936585,0.004776975,0.0003082187,0.0005081542,0.0002669826,0.0002687963,0.0001507695,0.00002814173,0.00003338989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1308533,"threshold_uncertainty_score":0.9999306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05574559710314367,"score_gpt":0.3849257242669349,"score_spread":0.3291801271637912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}