{"id":"W1982101816","doi":"10.1158/1538-7445.am2012-1397","title":"Abstract 1397: A novel ligand-independent Flt3 allele drives RANKL expression in a murine model of B-precursor acute lymphoblastic leukemia with CNS dissemination","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biology; Progenitor cell; Cancer research; Haematopoiesis; Receptor tyrosine kinase; Tyrosine kinase; Precursor cell; Molecular biology; Signal transduction; Stem cell; Cell biology; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005279726,0.001047951,0.0004744735,0.001277744,0.0005190777,0.0007613389,0.0009764503,0.001419432,0.00470025],"category_scores_gemma":[0.0001711745,0.0006110051,0.0006833408,0.0004030178,0.001184539,0.0005813207,0.0004918728,0.002993844,0.001918716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001169951,"about_ca_system_score_gemma":0.0008843379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001318673,"about_ca_topic_score_gemma":0.001992295,"domain_scores_codex":[0.9990256,0.0001707908,0.00009483239,0.0001541497,0.000338347,0.0002162967],"domain_scores_gemma":[0.9994977,0.00004395686,0.0001592265,0.0000610776,0.00003218806,0.0002059208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003653138,0.0003501201,0.0001255168,0.00006496131,0.0000100891,0.0001768631,0.000050791,0.0001956944,0.9964408,0.001014912,0.0002654495,0.0009394987],"study_design_scores_gemma":[0.0004895737,0.003004632,0.001492496,0.00004107188,0.00005234755,0.0009513479,0.000124611,0.003428372,0.9785922,0.0003463542,0.01145437,0.0000225956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812214,0.001257609,0.006910169,0.001332804,0.0002551941,0.0004424178,0.003102219,0.0007259556,0.004752257],"genre_scores_gemma":[0.9744639,0.001024148,0.007512914,0.0003317829,0.00005574153,0.0006373452,0.002000673,0.0002020135,0.01377144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00470025,"threshold_uncertainty_score":0.01572388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04111707338153089,"score_gpt":0.3694985977590538,"score_spread":0.3283815243775229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}