{"id":"W1982144228","doi":"10.1074/jbc.m609838200","title":"Crystal Structure of Human Inosine Triphosphatase","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Cancerfonden; VINNOVA; Stiftelsen för Strategisk Forskning; Canadian Institutes of Health Research; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"ITPA; Inosine; Nucleotide; Biochemistry; Chemistry; Xanthine; Active site; Inosine monophosphate; Purine; Enzyme; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004064274,0.0009522675,0.001383221,0.0002915457,0.0008455193,0.001628347,0.001586634,0.00118989,0.005222223],"category_scores_gemma":[0.0009144081,0.0004939801,0.0003962107,0.0008429109,0.0003111401,0.0007133883,0.0004540832,0.002874398,0.001497921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001437512,"about_ca_system_score_gemma":0.001457141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006794481,"about_ca_topic_score_gemma":0.005213002,"domain_scores_codex":[0.9995332,0.00007587327,0.00001966523,0.00009413898,0.0001993835,0.00007778938],"domain_scores_gemma":[0.9995434,0.00009912521,0.00005183579,0.00001572663,0.0002131037,0.00007689503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005108402,0.001929309,0.02249747,0.004774903,0.001024297,0.007780697,0.003030688,0.03701333,0.5409659,0.01578465,0.2368464,0.123244],"study_design_scores_gemma":[0.002638483,0.00237896,0.0614322,0.0006806563,0.0009039048,0.00773783,0.003423863,0.164812,0.154985,0.009886505,0.5905392,0.0005814189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8455257,0.04967567,0.02163613,0.007899183,0.002416328,0.0004767423,0.02271051,0.002375739,0.04728397],"genre_scores_gemma":[0.8292223,0.02024521,0.03028129,0.002253415,0.0003696267,0.0005623545,0.08965904,0.0005856273,0.02682111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006794481,"threshold_uncertainty_score":0.01747012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01061213368569759,"score_gpt":0.2454877791066524,"score_spread":0.2348756454209548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}