{"id":"W1982155496","doi":"10.1016/j.str.2008.03.008","title":"Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3)","year":2008,"lang":"en","type":"article","venue":"Structure","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Hospital for Sick Children; Wellcome Trust","keywords":"Erythropoietin-producing hepatocellular (Eph) receptor; Autophosphorylation; Ephrin; Receptor tyrosine kinase; Protein kinase domain; Cell biology; Biology; Allosteric regulation; Receptor Protein-Tyrosine Kinases; Signal transduction; Biochemistry; EPH receptor A2; Tyrosine kinase; SH3 domain; Kinase; Receptor; Protein kinase A; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001079757,0.0001570794,0.000113562,0.0001186359,0.0001971737,0.0003980785,0.000175228,0.0001919943,0.0005694822],"category_scores_gemma":[0.0001938448,0.0001276631,0.0001526369,0.00008211994,0.0003025857,0.0002757843,0.0003492245,0.0004064241,0.0002715673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005446959,"about_ca_system_score_gemma":0.0002730966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009446024,"about_ca_topic_score_gemma":0.001866003,"domain_scores_codex":[0.9999076,0.00001546747,0.000004528501,0.00002173488,0.00002332083,0.00002733876],"domain_scores_gemma":[0.999874,0.00002761618,0.00004422103,0.00001329396,0.00001536348,0.00002553702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001081978,0.000006721523,0.0002346126,0.000003788678,0.000001392389,0.0000564008,0.00001431022,0.00008525475,0.9981065,0.0005225717,0.00003186703,0.0008284082],"study_design_scores_gemma":[0.00003709182,0.0001599161,0.03078193,0.000006771156,0.00001688755,0.0006055916,0.0001329286,0.007238754,0.9561296,0.001005686,0.003870436,0.00001445203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99613,0.0005025789,0.002054282,0.00006271915,0.00002052402,0.000002947784,0.0000704296,0.00002759792,0.001128844],"genre_scores_gemma":[0.9984261,0.0001408461,0.0005811675,0.00002952256,0.000006784473,0.000003955654,0.00009083059,0.00001537917,0.0007054104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009446024,"threshold_uncertainty_score":0.003952086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944666123301277,"score_gpt":0.2473960479073512,"score_spread":0.2179493866743384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}