{"id":"W1982191132","doi":"10.1007/s40272-014-0098-9","title":"Ethics Review of Pediatric Multi-Center Drug Trials","year":2014,"lang":"en","type":"review","venue":"Pediatric Drugs","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Clinical Evaluative Sciences; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Engineering ethics; Process (computing); Research ethics; Medicine; Pediatric research; Informed consent; Human research; Clinical trial; Ethical issues; Risk analysis (engineering); Management science; Alternative medicine; Computer science; Pediatrics; Pathology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.05749384,0.0008199395,0.003386449,0.004326249,0.0007586906,0.003014312,0.002086931,0.003203555,0.00322389],"category_scores_gemma":[0.1501393,0.0006190726,0.002251694,0.004478222,0.001690606,0.002191603,0.001926046,0.002476771,0.0004012572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004160474,"about_ca_system_score_gemma":0.01854067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001452918,"about_ca_topic_score_gemma":0.004055384,"domain_scores_codex":[0.9345247,0.04169767,0.01412729,0.001221211,0.007721141,0.0007079357],"domain_scores_gemma":[0.7919291,0.1651016,0.02575401,0.003412433,0.01258608,0.001216731],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005955455,0.00008693945,0.001372588,0.3227263,0.002605309,0.0003719072,0.0004701828,0.0004007874,0.0003620519,0.01198011,0.03930076,0.6197276],"study_design_scores_gemma":[0.0005307412,0.0002418672,0.003065742,0.4796252,0.005929555,0.001323226,0.0003406174,0.0001817496,0.0006899749,0.007518927,0.5005098,0.00004255897],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003346605,0.9935088,0.0004699136,0.003555352,0.0004161743,0.0002135483,0.00008634173,0.000006242459,0.001408964],"genre_scores_gemma":[0.0070452,0.9850153,0.001989475,0.004414171,0.0005812751,0.0004834357,0.0001132118,0.000008180914,0.0003496862],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9967964,"threshold_uncertainty_score":0.3040601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3120108919812694,"score_gpt":0.5234792384022355,"score_spread":0.2114683464209662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}