{"id":"W1982193571","doi":"10.1021/jm501916k","title":"C-Terminal Modifications of Apelin-13 Significantly Change Ligand Binding, Receptor Signaling, and Hypotensive Action","year":2015,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Apelin; Terminal (telecommunication); Receptor; Action (physics); Ligand (biochemistry); Pharmacology; Signal transduction; Stereochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001063098,0.0002307825,0.0002369007,0.00007965007,0.00008264487,0.0001514262,0.0002037521,0.0002463683,0.001243044],"category_scores_gemma":[0.0002044436,0.00007765242,0.0002407845,0.0001073197,0.0001385671,0.0001892937,0.0001641768,0.0005982145,0.0002388296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001217417,"about_ca_system_score_gemma":0.0001142463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000304539,"about_ca_topic_score_gemma":0.0002891113,"domain_scores_codex":[0.9999294,0.00001076158,0.000007469177,0.00001380166,0.00001723811,0.00002120607],"domain_scores_gemma":[0.9999207,0.00001492502,0.00002288383,0.000008522465,0.00001009092,0.00002283102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003645595,0.00003828553,0.0001142384,0.00004558568,0.00001077334,0.0001531486,0.00001542924,0.0001242386,0.9966567,0.00007465608,0.00003087689,0.002371569],"study_design_scores_gemma":[0.00005135955,0.001023497,0.002570737,0.000006790548,0.00003585023,0.0005588086,0.00002087545,0.0004784263,0.9917486,0.00004713584,0.003446035,0.00001202843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956917,0.001066104,0.001629604,0.00005155014,0.00003474173,0.00002553735,0.0001383713,0.00002132863,0.001341059],"genre_scores_gemma":[0.9946956,0.000936501,0.002447534,0.0001061168,0.00001366938,0.00002286279,0.0002921248,0.00001328122,0.001472351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243044,"threshold_uncertainty_score":0.004158437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1379743262534954,"score_gpt":0.3657363748385353,"score_spread":0.2277620485850399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}