{"id":"W1982193571","doi":"10.1021/jm501916k","title":"C-Terminal Modifications of Apelin-13 Significantly Change Ligand Binding, Receptor Signaling, and Hypotensive Action","year":2015,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Apelin; Terminal (telecommunication); Receptor; Action (physics); Ligand (biochemistry); Pharmacology; Signal transduction; Stereochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001275409,0.0001856836,0.0005592719,0.0001978438,0.00005119499,0.00001221617,0.000178466,0.0003010621,0.0001619292],"category_scores_gemma":[0.002487822,0.0001395206,0.0001202827,0.0003217995,0.0004494471,0.0001204188,0.00004740519,0.0009922076,0.00001395526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001789998,"about_ca_system_score_gemma":0.0006800062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002330948,"about_ca_topic_score_gemma":5.257883e-7,"domain_scores_codex":[0.9971994,0.00004829874,0.0008140954,0.0002120294,0.001438042,0.0002881791],"domain_scores_gemma":[0.9964496,0.0002297661,0.0007095567,0.0001985095,0.001429246,0.0009833393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001041287,0.0002253634,0.001219139,0.0003842187,0.0001458193,0.0002632825,0.000819124,0.000001092165,0.9803715,0.000001429744,0.006513082,0.009014664],"study_design_scores_gemma":[0.00843637,0.002811761,0.005519175,0.003023736,0.0009233961,0.005614098,0.01162167,0.0005552162,0.9534904,0.0001499777,0.007509727,0.0003444962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934092,0.001895966,0.0001488811,0.00369767,0.0002034234,0.0001790233,0.00001231492,0.0000117859,0.0004417749],"genre_scores_gemma":[0.995876,0.0008652559,0.0007160518,0.0001469837,0.00157797,0.000005198517,0.00001819372,0.00002340711,0.0007709973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02688112,"threshold_uncertainty_score":0.5689487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1379743262534954,"score_gpt":0.3657363748385353,"score_spread":0.2277620485850399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}