{"id":"W1982194661","doi":"10.1371/journal.ppat.1003124","title":"IFITM Proteins Restrict Viral Membrane Hemifusion","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":370,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; U.S. Public Health Service; National Institute on Aging; National Institutes of Health; University of Missouri","keywords":"Lipid bilayer fusion; Cell biology; Biology; Viral envelope; Transmembrane protein; Viral entry; Cell fusion; Hemagglutinin (influenza); Membrane curvature; Membrane protein; Retrovirus; Cell membrane; Biophysics; Membrane; Lipid bilayer; Viral replication; Cell; Biochemistry; Virus; Virology; Glycoprotein; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00009860136,0.0002005421,0.0002544028,0.0001220138,0.0001921793,0.00002641889,0.0002455942,0.0002457376,0.005605505],"category_scores_gemma":[0.00017545,0.0001617478,0.0001189628,0.0001101506,0.000118709,0.0001185336,0.0001249686,0.0002946494,0.0117472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003683058,"about_ca_system_score_gemma":0.00004932858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000970206,"about_ca_topic_score_gemma":0.000003029852,"domain_scores_codex":[0.9987061,0.000231998,0.0002808942,0.0002876946,0.0000469902,0.0004463443],"domain_scores_gemma":[0.999313,0.00008401705,0.0000808503,0.0003963681,0.00009434293,0.00003144403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001279235,0.0001914725,0.0002434251,0.00001585325,0.00006899679,0.000008785233,0.000241116,3.207296e-7,0.9926186,0.0002250537,0.003571408,0.002687077],"study_design_scores_gemma":[0.0006755298,0.0003571523,0.00454324,0.00004689902,0.00002970838,0.0000566366,0.0001507774,0.00001055524,0.9781016,0.00007629347,0.01572952,0.0002220484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904248,0.0009074504,0.00002952667,0.0003353801,0.0003490925,0.0006265701,0.0000322901,0.0001658415,0.007129109],"genre_scores_gemma":[0.9834307,0.00009504606,0.0001737058,0.0002540152,0.00004306128,0.0001538864,0.00007409893,0.00002770995,0.01574778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01451693,"threshold_uncertainty_score":0.9953035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346827660182359,"score_gpt":0.2116541583656291,"score_spread":0.1981858817638055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}