{"id":"W1982223048","doi":"10.1074/jbc.m112.434365","title":"Minor Modifications to the Phosphate Groups and the C3′ Acyl Chain Length of Lipid A in Two Bordetella pertussis Strains, BP338 and 18-323, Independently Affect Toll-like Receptor 4 Protein Activation","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Centre National de la Recherche Scientifique","keywords":"Lipid A; TLR4; Bordetella pertussis; Receptor; Biochemistry; Toll-like receptor; Chemistry; Locus (genetics); Gene; Biology; Lipopolysaccharide; Bacteria; Genetics; Innate immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008197668,0.0004325014,0.0001804797,0.0001941387,0.000130265,0.0002202016,0.0002548008,0.0002834782,0.001032259],"category_scores_gemma":[0.0002160106,0.0001675019,0.0003679349,0.0001998106,0.0002680074,0.0001091824,0.0002168104,0.0005776371,0.000254043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003441996,"about_ca_system_score_gemma":0.0002582235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001713606,"about_ca_topic_score_gemma":0.00176538,"domain_scores_codex":[0.9998192,0.00003209014,0.00002409258,0.00003707104,0.00004517122,0.00004235519],"domain_scores_gemma":[0.9997833,0.0000461811,0.00008223992,0.00002467433,0.00001204927,0.00005149707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002116193,0.00003647243,0.0003730769,0.00001140782,0.000003750907,0.00004015049,0.00000961804,0.00001734688,0.9988995,0.00001465393,0.000006254085,0.0003762607],"study_design_scores_gemma":[0.00002578984,0.0005761795,0.02238415,0.000005750618,0.00004428911,0.0003528927,0.00006092988,0.0003219888,0.9753689,0.00002569214,0.0008250734,0.000008365695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989931,0.0000946145,0.0004212531,0.00002461047,0.000007757696,0.00001361053,0.0002308317,0.00001596023,0.0001982805],"genre_scores_gemma":[0.9972664,0.0001477423,0.0009425611,0.00003615809,0.00000413769,0.00003632121,0.0007679256,0.00002066542,0.0007780588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001713606,"threshold_uncertainty_score":0.003453255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856399766332233,"score_gpt":0.2531230639914746,"score_spread":0.2345590663281522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}