{"id":"W1982223225","doi":"10.1523/jneurosci.5456-13.2014","title":"Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum","year":2014,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital","funders":"","keywords":"Vesicular monoamine transporter 2; Vesicular monoamine transporter; Striatum; Dopamine; Synaptic vesicle; Neurodegeneration; Putamen; MPTP; Parkinson's disease; Vesicular transport protein; Neuroscience; Chemistry; Axoplasmic transport; Caudate nucleus; Monoamine neurotransmitter; Biology; Internal medicine; Vesicle; Biochemistry; Dopamine transporter; Dopaminergic; Medicine; Serotonin; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162931,0.0001986011,0.0003782427,0.0003200208,0.0002794344,0.0003660509,0.0001608874,0.0004669377,0.0004818722],"category_scores_gemma":[0.0002167781,0.0000945567,0.0001203642,0.000268834,0.0005793259,0.0002159334,0.0001966898,0.0001740924,0.0001088957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001458318,"about_ca_system_score_gemma":0.0001164189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008323071,"about_ca_topic_score_gemma":0.0009039139,"domain_scores_codex":[0.999913,0.00001576739,0.000008837264,0.00003138316,0.00002075343,0.00001035331],"domain_scores_gemma":[0.999921,0.00001426469,0.00002865362,0.000008296629,0.00001307432,0.00001478934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001971853,0.0001482967,0.2853459,0.0008510119,0.0004183821,0.01126289,0.001687627,0.0002520685,0.6397664,0.0008457222,0.0005195207,0.05693036],"study_design_scores_gemma":[0.00004621328,0.001672533,0.8716769,0.00007259458,0.0002398542,0.05725156,0.001063451,0.0004505671,0.05631289,0.0008841089,0.01030334,0.00002601811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868067,0.01187746,0.0003173576,0.000115006,0.00001478441,0.000008677411,0.00008815258,0.000008627101,0.0007632176],"genre_scores_gemma":[0.9951913,0.004275146,0.0001723486,0.00003538528,0.00001751186,0.000002889245,0.0001104796,0.000001733626,0.0001930834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008323071,"threshold_uncertainty_score":0.001654923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02957687639171931,"score_gpt":0.3033957752630307,"score_spread":0.2738188988713114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}