{"id":"W1982232007","doi":"10.1371/journal.pone.0071044","title":"Immuno-Regulatory Function of Indoleamine 2,3 Dioxygenase through Modulation of Innate Immune Responses","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"CIHR Skin Research Training Centre; Canadian Institutes of Health Research","keywords":"Indoleamine 2,3-dioxygenase; Proinflammatory cytokine; Kynurenine; Immune system; Islet; Transplantation; Cancer research; Immunology; Apoptosis; Viability assay; Biology; Cell biology; Inflammation; Medicine; Internal medicine; Endocrinology; Biochemistry; Diabetes mellitus; Tryptophan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104773,0.0002011318,0.0001543936,0.0001049067,0.00007694502,0.0001971837,0.00009436584,0.0001345654,0.0006080079],"category_scores_gemma":[0.00004878376,0.00004151217,0.0002245343,0.00005774403,0.0001327707,0.0001268554,0.00009211845,0.0002726743,0.0001041085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001435628,"about_ca_system_score_gemma":0.0001677308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000242441,"about_ca_topic_score_gemma":0.0005622449,"domain_scores_codex":[0.9999447,0.00001211221,0.000004698404,0.000009085407,0.000008193716,0.00002127941],"domain_scores_gemma":[0.9999634,0.000005067864,0.00001051428,0.000004667364,0.00000566916,0.00001065474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001673927,0.00003382038,0.0002492979,0.00003965849,0.000003849135,0.0000418014,0.000007252455,0.00002004074,0.9981182,0.00005626045,0.00001464838,0.001247885],"study_design_scores_gemma":[0.00002289221,0.0005982203,0.008562668,0.00000987797,0.00002382472,0.0001424571,0.00003928617,0.0004867986,0.9884781,0.00007228721,0.001560298,0.000003285137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919916,0.004712606,0.001868561,0.00008526858,0.0000311608,0.00001940707,0.0001321292,0.00002901803,0.001130135],"genre_scores_gemma":[0.9957415,0.001936148,0.001007746,0.00005044588,0.00001232314,0.00001821623,0.00009902241,0.000003463405,0.001131122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006080079,"threshold_uncertainty_score":0.002033949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04714354177398092,"score_gpt":0.23201370379655,"score_spread":0.1848701620225691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}