{"id":"W1982237778","doi":"10.1021/ja0281232","title":"An Efficient RNA-Cleaving DNA Enzyme that Synchronizes Catalysis with Fluorescence Signaling","year":2002,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Deoxyribozyme; Chemistry; DNA; RNA; Biomolecule; Biochemistry; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000260645,0.0003493813,0.0002931925,0.0001291999,0.000107299,0.0003878534,0.0003089109,0.0003880291,0.0005326485],"category_scores_gemma":[0.0003434288,0.0001789312,0.0001737844,0.0001180927,0.000215716,0.00026194,0.0002036985,0.0005406804,0.0004263204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002376312,"about_ca_system_score_gemma":0.0001892865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001495649,"about_ca_topic_score_gemma":0.0002195674,"domain_scores_codex":[0.9997357,0.00003670364,0.00001620231,0.00009156326,0.00009171534,0.0000280611],"domain_scores_gemma":[0.9998261,0.0000379316,0.00004559808,0.00002253923,0.00003262575,0.00003505986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002301391,0.00001248746,0.0001150099,0.00002816318,0.000002605778,0.00002531832,0.000006198749,0.00009030371,0.9960523,0.0002645725,0.00003090856,0.003349063],"study_design_scores_gemma":[0.000004291384,0.00006144139,0.00015201,0.000001118399,0.000002699603,0.0001870909,0.000002062458,0.0005503903,0.9967865,0.00001728526,0.002232668,0.000002420852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8444491,0.004091743,0.1440824,0.0002858513,0.0001716639,0.000213507,0.000379776,0.000586412,0.005739595],"genre_scores_gemma":[0.8980687,0.001269484,0.0940759,0.00008805597,0.00002265946,0.00008348293,0.0004131669,0.00006011422,0.005918342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005326485,"threshold_uncertainty_score":0.00178194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008149871054068046,"score_gpt":0.2398805744621753,"score_spread":0.2317307034081073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}