{"id":"W1982251171","doi":"10.1074/jbc.m508416200","title":"Human Serum from Patients with Septic Shock Activates Transcription Factors STAT1, IRF1, and NF-κB and Induces Apoptosis in Human Cardiac Myocytes","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Laurentian University","funders":"","keywords":"Apoptosis; IRF1; Septic shock; NF-κB; Myocyte; STAT1; Cell biology; Transcription factor; Cardiac myocyte; Heat shock factor; NFKB1; Cancer research; Chemistry; Heat shock protein; Internal medicine; Biology; Sepsis; Hsp70; Medicine; Signal transduction; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002783028,0.000390713,0.0003138336,0.0003228493,0.000143704,0.0002933706,0.00008253226,0.0002311112,0.001659411],"category_scores_gemma":[0.0005512441,0.00009636817,0.0001684096,0.0002699155,0.0001871817,0.0000890287,0.0002253697,0.0002919674,0.0004435593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001671662,"about_ca_system_score_gemma":0.0002195858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002833715,"about_ca_topic_score_gemma":0.0002608884,"domain_scores_codex":[0.9998004,0.00006542908,0.00002396451,0.00002400532,0.0000529433,0.00003337411],"domain_scores_gemma":[0.9998393,0.0000346735,0.00005148356,0.0000178265,0.00002937627,0.00002737344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00456654,0.0002033117,0.04559708,0.0002621546,0.00008312889,0.001709479,0.0003416573,0.0001527884,0.9263552,0.0001599014,0.0008444941,0.01972429],"study_design_scores_gemma":[0.0004500257,0.006911703,0.3316474,0.0001213662,0.000196108,0.0155741,0.0008233511,0.00167856,0.6328232,0.0006422123,0.009101223,0.00003063415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940327,0.002690623,0.001802492,0.0002218783,0.00004386502,0.00002427317,0.0003233878,0.00005002286,0.0008108706],"genre_scores_gemma":[0.9969856,0.0009395982,0.0007023601,0.0001030569,0.00002166587,0.00001696598,0.0007515012,0.000003969357,0.0004753359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001659411,"threshold_uncertainty_score":0.005551338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01278259443218838,"score_gpt":0.2233877042421999,"score_spread":0.2106051098100115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}