{"id":"W1982257974","doi":"10.1089/hum.2013.063","title":"From Mutation Identification to Therapy: Discovery and Origins of the First Approved Gene Therapy in the Western World","year":2013,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"Columbia university; Medicine; Library science; Hum; Family medicine; History; Art history; Media studies; Sociology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491069,0.0001508908,0.0001191279,0.00004808263,0.00008810225,0.00008464899,0.000311647,0.00005471913,0.00001270413],"category_scores_gemma":[0.000003912592,0.00009476055,0.00006010868,0.0001354726,0.00004916375,0.00001113444,0.00003316116,0.0000642386,0.00000288371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001394539,"about_ca_system_score_gemma":0.00001409691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006045459,"about_ca_topic_score_gemma":0.0005918582,"domain_scores_codex":[0.9991644,0.00006037211,0.0002287922,0.0002687578,0.000130843,0.0001468521],"domain_scores_gemma":[0.9993262,0.00001712201,0.00007781864,0.0005163205,0.00003834572,0.00002416243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004126685,0.00006240088,0.005829271,0.000002533941,0.00003668207,2.398526e-7,0.001715593,0.000280602,0.9848996,0.00001868922,0.0002184155,0.006894696],"study_design_scores_gemma":[0.0007127874,0.0001245479,0.3208234,0.000006549574,0.000002732181,0.000001619581,0.00009948309,0.00003085579,0.6708205,0.0001971135,0.007063212,0.0001172146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949012,0.002178891,0.001458514,0.0006109844,0.00009943236,0.0007064913,0.00001207533,0.000006664484,0.00002570729],"genre_scores_gemma":[0.9975291,0.0009278686,0.00009932627,0.0007757955,0.0002235496,0.0001474528,0.00005498569,0.00002367151,0.0002182417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3149941,"threshold_uncertainty_score":0.3864223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459252530517025,"score_gpt":0.285754851970255,"score_spread":0.2711623266650847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}