{"id":"W1982271708","doi":"10.1016/s0223-5234(00)01173-9","title":"Cytotoxic 2,6-bis(arylidene)cyclohexanones and related compounds","year":2000,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"","keywords":"Chemistry; Cytotoxicity; Cytotoxic T cell; Mannich base; Stereochemistry; Molecule; Potency; L1210 cells; Mannich reaction; In vitro; Cell culture; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008050873,0.0002088541,0.0003765858,0.00001887448,0.00009255429,0.00003278122,0.0003280126,0.00008052984,0.01564416],"category_scores_gemma":[0.0001930072,0.0001448732,0.0001378332,0.00007335444,0.0002416689,0.00008554089,0.00004599987,0.0005845905,0.00003334665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003610103,"about_ca_system_score_gemma":0.00003578903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002185725,"about_ca_topic_score_gemma":9.163202e-8,"domain_scores_codex":[0.9985313,0.00009407983,0.0005997805,0.0002118992,0.0003319813,0.0002309975],"domain_scores_gemma":[0.9989614,0.000181726,0.0003287088,0.0001861768,0.00006246923,0.0002794508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002173144,0.0001275189,0.001385476,0.00008764015,0.00008750572,0.001145989,0.00009174112,0.000002668057,0.9467065,0.000001225077,0.001259819,0.04888657],"study_design_scores_gemma":[0.004421084,0.0004262087,0.03804468,0.001462683,0.0003133283,0.01970664,0.0006677699,0.00005551744,0.7788584,0.0001992249,0.1549716,0.0008728597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7732342,0.001144459,0.000002414364,0.0003827109,0.00003889687,0.00001017192,0.000003623815,0.00002393745,0.2251596],"genre_scores_gemma":[0.9936358,0.0005906717,0.0001144833,0.00008589034,0.0006693265,2.787503e-7,0.000002802041,0.00002206835,0.004878646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2204017,"threshold_uncertainty_score":0.9852557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157999224360309,"score_gpt":0.2088242179880508,"score_spread":0.1972442257444477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}