{"id":"W1982291583","doi":"10.1038/nrclinonc.2013.158","title":"Drug rechallenge and treatment beyond progression—implications for drug resistance","year":2013,"lang":"en","type":"review","venue":"Nature Reviews Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":281,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Medicine; Drug resistance; Disease; Drug; Intensive care medicine; Cancer; Chemotherapy; Pharmacotherapy; Oncology; Internal medicine; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001163736,0.0006561058,0.005675932,0.0001324899,0.0001996822,0.00002457044,0.0002141018,0.001608655,0.00005992975],"category_scores_gemma":[0.001114443,0.0003639611,0.001505202,0.0002662466,0.0002184687,0.00006385279,0.00007041168,0.001277065,0.0001047976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009146635,"about_ca_system_score_gemma":0.001774071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003004404,"about_ca_topic_score_gemma":0.0001456122,"domain_scores_codex":[0.9952732,0.0007358662,0.002315662,0.001133455,0.0001309183,0.0004109401],"domain_scores_gemma":[0.9936004,0.003153679,0.001534896,0.0009709836,0.0002643573,0.0004756745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002948089,0.0007946054,0.00001727366,0.008180963,0.0005843521,0.00000715714,0.00003840335,9.902925e-10,2.401655e-8,0.00137693,0.1006323,0.8883384],"study_design_scores_gemma":[0.001861778,0.0006833143,0.00003368067,0.01093169,0.009799196,0.00004751674,0.000006761469,1.362426e-7,5.746688e-8,0.000567487,0.9757857,0.0002827268],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[8.810046e-7,0.9610145,0.00001124553,0.014842,0.0007851965,0.01489002,0.0001840925,0.00006389058,0.008208148],"genre_scores_gemma":[6.21763e-7,0.9378206,0.02388638,0.0009428245,0.001073055,0.01343084,0.0008859881,0.0000831114,0.02187661],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8880557,"threshold_uncertainty_score":0.9998812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1952067673287653,"score_gpt":0.5925349983358467,"score_spread":0.3973282310070814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}