{"id":"W1982291583","doi":"10.1038/nrclinonc.2013.158","title":"Drug rechallenge and treatment beyond progression—implications for drug resistance","year":2013,"lang":"en","type":"review","venue":"Nature Reviews Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":281,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Medicine; Drug resistance; Disease; Drug; Intensive care medicine; Cancer; Chemotherapy; Pharmacotherapy; Oncology; Internal medicine; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007513046,0.0005958555,0.001616945,0.001073216,0.0002131945,0.001101864,0.0008633548,0.001439827,0.003640369],"category_scores_gemma":[0.001097332,0.0002520451,0.0006622848,0.001016945,0.0006302308,0.001323851,0.0005542651,0.002677798,0.00134226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008860915,"about_ca_system_score_gemma":0.0009578345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067676,"about_ca_topic_score_gemma":0.003617321,"domain_scores_codex":[0.9997378,0.00005322332,0.00003397954,0.00005398083,0.0000922355,0.00002876445],"domain_scores_gemma":[0.9994639,0.0003366796,0.00007468965,0.00001472262,0.00007860652,0.00003140612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008905517,0.0000451826,0.0002452875,0.005302505,0.0001124517,0.0001713901,0.00003053368,0.0004242938,0.001390206,0.004245353,0.03802941,0.9499143],"study_design_scores_gemma":[0.00005256048,0.0001479937,0.001171901,0.003318336,0.0001907672,0.001601876,0.00004666176,0.0002444836,0.0005353972,0.00451103,0.9881538,0.00002525355],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001131843,0.998144,0.0001141602,0.0006834401,0.0001489591,0.000002145258,0.00001522768,0.000006907464,0.0007719383],"genre_scores_gemma":[0.001999974,0.9957042,0.0002319384,0.0009587531,0.0003056817,0.000006839853,0.00003151774,0.000002740625,0.0007583617],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003640369,"threshold_uncertainty_score":0.0121783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1952067673287653,"score_gpt":0.5925349983358467,"score_spread":0.3973282310070814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}