{"id":"W1982307191","doi":"10.1038/gt.2011.181","title":"dsAAV8-mediated gene transfer and β-cell expression of IL-4 and β-cell growth factors are capable of reversing early-onset diabetes in NOD mice","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Deutsche Forschungsgemeinschaft; Michael Smith Health Research BC; Stem Cell Network","keywords":"NOD mice; Nod; Genetic enhancement; Biology; Immunology; Diabetes mellitus; In vivo; Cell growth; Adoptive cell transfer; T cell; Cancer research; Endocrinology; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000258084,0.0002078399,0.0002952621,0.0001233415,0.00005004486,0.000007573411,0.0001808071,0.0001904106,0.00003354067],"category_scores_gemma":[0.00001112395,0.0001863904,0.00006056528,0.0001365232,0.000163591,0.00001033561,0.00004730445,0.0001115341,7.148424e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009282209,"about_ca_system_score_gemma":0.00004431031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002067306,"about_ca_topic_score_gemma":0.00006673654,"domain_scores_codex":[0.9987199,0.0001723464,0.000269704,0.0003642794,0.0001569378,0.0003168541],"domain_scores_gemma":[0.9994128,0.00003341087,0.00008411118,0.0002796939,0.0000876567,0.000102274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001261253,0.0001739445,0.1012911,0.00005590571,0.00002398749,0.000001460426,0.0009417416,0.000001824492,0.8960716,9.554523e-8,0.00002490008,0.0001522966],"study_design_scores_gemma":[0.00213818,0.00171352,0.02385661,0.00002663514,0.000007944776,7.671711e-7,0.000179765,0.000008841129,0.9718303,0.00002053161,0.00003089652,0.0001860197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938655,0.005578424,0.00002623151,0.00001325498,0.00002854662,0.0002847007,0.0001461826,0.000006273903,0.00005083756],"genre_scores_gemma":[0.994589,0.004914606,0.0002761933,0.00005118272,0.00002036733,0.00001044037,0.00005844407,0.00003752885,0.00004224698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07743445,"threshold_uncertainty_score":0.7600782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0192366854660026,"score_gpt":0.2270360015166855,"score_spread":0.2077993160506829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}