{"id":"W1982313226","doi":"10.1371/journal.pone.0048670","title":"Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; China Scholarship Council","keywords":"Wnt signaling pathway; AXIN2; Cancer research; Colorectal cancer; Cell growth; Cancer cell; WNT3A; Breast cancer; Biology; Cell biology; Chemistry; Cancer; Molecular biology; Signal transduction; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236904,0.0003099751,0.0003417463,0.0002111937,0.0001210162,0.0002471801,0.0002321984,0.0002105024,0.001592408],"category_scores_gemma":[0.00008835236,0.0001572319,0.0002358701,0.0002428049,0.0001573017,0.0001285715,0.0001576548,0.0006697394,0.0004589652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003513775,"about_ca_system_score_gemma":0.0002842558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001096993,"about_ca_topic_score_gemma":0.002284036,"domain_scores_codex":[0.9998602,0.00001835155,0.00001698542,0.00002864472,0.00003972578,0.00003605973],"domain_scores_gemma":[0.9999427,0.00001342011,0.00001635075,0.000008455054,0.000005250042,0.0000139008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001401768,0.00003839757,0.00006647674,0.00005671033,0.000008764002,0.00002865817,0.00001056193,0.00008007642,0.9983377,0.00007584615,0.0000913453,0.001065094],"study_design_scores_gemma":[0.00003948197,0.0002952066,0.001789785,0.000004725417,0.00001649482,0.0001294486,0.0000129688,0.000808329,0.9940273,0.00002920835,0.002844027,0.000003080931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879674,0.004890194,0.002316379,0.0002612875,0.00008198851,0.00005417632,0.001202169,0.0002216962,0.003004787],"genre_scores_gemma":[0.9921647,0.002038768,0.001560909,0.00006937511,0.000009688609,0.00006803302,0.001026454,0.00001972164,0.003042281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592408,"threshold_uncertainty_score":0.005327106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0249132995485932,"score_gpt":0.2261422063214479,"score_spread":0.2012289067728547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}