{"id":"W1982313226","doi":"10.1371/journal.pone.0048670","title":"Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; China Scholarship Council","keywords":"Wnt signaling pathway; AXIN2; Cancer research; Colorectal cancer; Cell growth; Cancer cell; WNT3A; Breast cancer; Biology; Cell biology; Chemistry; Cancer; Molecular biology; Signal transduction; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013128,0.00008091779,0.0001089854,0.00004070893,0.00002208073,0.000006877346,0.00003456124,0.0000831119,0.00007951007],"category_scores_gemma":[0.00001017659,0.00007990169,0.00001386567,0.00007976333,0.00003844391,0.00000872901,0.00003454691,0.00004425501,7.68473e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001686043,"about_ca_system_score_gemma":0.00003765274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004107569,"about_ca_topic_score_gemma":0.0000203259,"domain_scores_codex":[0.9994181,0.0000241924,0.0001621657,0.0001340907,0.0001178119,0.0001435765],"domain_scores_gemma":[0.9997548,0.000008704564,0.00007197878,0.00005595647,0.0000700502,0.00003844668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003619881,0.0002530284,0.0618828,0.00005815498,0.00004024529,1.24393e-7,0.0002008978,0.00003970262,0.9372182,0.000003990639,0.00003428089,0.0002323456],"study_design_scores_gemma":[0.000241401,0.00002803422,0.008133688,0.0001638251,0.00002877786,4.919019e-7,0.00007202249,0.00002162038,0.9911721,0.00001836839,0.00001355844,0.0001060678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977006,0.001965156,0.00004740649,0.00005567183,0.00002891821,0.0001119405,0.0000203846,0.000004922685,0.00006504152],"genre_scores_gemma":[0.9985054,0.0008274928,0.0003396434,0.00004770288,0.0001390229,0.00003268268,0.00004110514,0.00001080311,0.00005621384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05395391,"threshold_uncertainty_score":0.3258296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0249132995485932,"score_gpt":0.2261422063214479,"score_spread":0.2012289067728547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}