{"id":"W1982328539","doi":"10.1007/s12035-013-8585-5","title":"IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice","year":2013,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Huntingtin; Protein kinase B; Endocrinology; Internal medicine; Huntington's disease; Biology; Signal transduction; Medicine; Disease; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002304153,0.0007735695,0.0006040735,0.0008429436,0.000372414,0.000502129,0.0006710671,0.0007922804,0.002538888],"category_scores_gemma":[0.0002117809,0.0003414729,0.0004196723,0.0002684265,0.0006955834,0.0003351232,0.0004544077,0.001813222,0.001125518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004143246,"about_ca_system_score_gemma":0.0004090361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002309235,"about_ca_topic_score_gemma":0.004612538,"domain_scores_codex":[0.999754,0.00002145831,0.00003613127,0.00005849771,0.00007255517,0.00005736385],"domain_scores_gemma":[0.9995188,0.00008373876,0.0001725787,0.00005780413,0.00002739942,0.0001397298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001664435,0.00004990443,0.0001786158,0.0000222742,0.000007156826,0.0001853706,0.00002041942,0.0000733442,0.9982569,0.00007231806,0.0001080236,0.0008592721],"study_design_scores_gemma":[0.00008282344,0.0002437957,0.004590439,0.00001431299,0.00002524224,0.0005235366,0.00009047537,0.0009862907,0.9913247,0.00009093453,0.00201008,0.00001735496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915177,0.0007999512,0.002349009,0.0003444142,0.0001432434,0.00003374935,0.002545487,0.0004353617,0.001830963],"genre_scores_gemma":[0.9809191,0.0007316436,0.0028243,0.0001018836,0.00003609803,0.000105,0.001649116,0.0002990742,0.0133337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002538888,"threshold_uncertainty_score":0.008493423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01230833896789392,"score_gpt":0.2462147858430316,"score_spread":0.2339064468751377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}