{"id":"W1982342857","doi":"10.1016/j.ymthe.2006.08.601","title":"530. The Effects DNA Molecular Weights and Conformations on Cell Uptake and the Binding Interaction with Cationic Polymers Used for Non-Viral Gene Delivery","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"DNA; Plasmid; Transfection; Molecular biology; Recombinant DNA; Polymer; Gene; Biophysics; Biology; In vitro recombination; Circular bacterial chromosome; Gene delivery; Chemistry; Biochemistry; Gene expression; Base pair; Molecular cloning","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003273823,0.0003305253,0.0002074044,0.0001427585,0.0001057357,0.000336255,0.0001697809,0.0003496945,0.002494621],"category_scores_gemma":[0.0003329187,0.0001343785,0.0001757282,0.0001336477,0.0001811604,0.0002107444,0.0001092097,0.0002599013,0.000729356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000332919,"about_ca_system_score_gemma":0.0001328391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001306131,"about_ca_topic_score_gemma":0.0009643233,"domain_scores_codex":[0.9996476,0.0001064108,0.00002265316,0.00005412473,0.0001064003,0.000062757],"domain_scores_gemma":[0.9997398,0.0001365023,0.00004350794,0.0000115794,0.00004139984,0.00002718558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000619029,0.00001270851,0.000173537,0.00002795008,0.000002652859,0.0000135429,0.00000929056,0.00003747743,0.9986695,0.00002691483,0.00001175093,0.0009528756],"study_design_scores_gemma":[0.000004548393,0.0002782079,0.00367712,0.000004038978,0.000008710243,0.00008220258,0.0000136493,0.0008433149,0.9941063,0.00001587755,0.0009617323,0.0000042718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919813,0.002188045,0.003684228,0.00005873035,0.00002436789,0.0000225361,0.0001369802,0.00003566268,0.001868173],"genre_scores_gemma":[0.9916271,0.0007945326,0.003395824,0.00004210947,0.000007387295,0.00003174612,0.0004290981,0.00001696703,0.003655165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002494621,"threshold_uncertainty_score":0.008345366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003934687521572501,"score_gpt":0.2102325437105732,"score_spread":0.2062978561890007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}