{"id":"W1982381743","doi":"10.1007/s11095-014-1598-6","title":"Dependence of PEI and PAMAM Gene Delivery on Clathrin- and Caveolin-Dependent Trafficking Pathways","year":2014,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institutes of Health; McMaster University","keywords":"Endocytic cycle; Endocytosis; Polyethylenimine; Clathrin; Gene delivery; Internalization; Cell biology; Transfection; Endosome; Caveolin; Biology; Receptor-mediated endocytosis; Pinocytosis; Caveolae; Signal transduction; Intracellular; Biochemistry; Cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001061376,0.000132341,0.0001559846,0.00008977551,0.0001100099,0.00003495846,0.0002021958,0.000132284,0.00002571312],"category_scores_gemma":[0.0002692465,0.0001184118,0.00004114325,0.00007161583,0.0002861296,0.000006056939,0.0003096197,0.0003409221,0.00001572135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001227879,"about_ca_system_score_gemma":0.0000564334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002487047,"about_ca_topic_score_gemma":0.00001822405,"domain_scores_codex":[0.9983004,0.0002341833,0.0001995251,0.000448912,0.0004115085,0.0004055081],"domain_scores_gemma":[0.9991394,0.0001676763,0.00003008823,0.0002433597,0.0001877114,0.0002317734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003510065,0.0000841286,0.002014716,0.00004936658,0.00003154185,0.00001101632,0.00008388019,0.00002760313,0.9435101,0.0004699796,0.0001270661,0.05323963],"study_design_scores_gemma":[0.0007609559,0.0009150486,0.003220972,0.00004121562,0.00001373754,0.00003084293,0.0001035777,0.002664351,0.9885949,0.0002483705,0.003236111,0.0001698554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964314,0.001639436,0.0002662898,0.0001450126,0.00005162165,0.0001566299,0.00001226852,0.000006820462,0.001290598],"genre_scores_gemma":[0.9964392,0.002921154,0.000127048,0.0001920752,0.0001517825,0.00001345875,0.000008754791,0.00001548823,0.0001310666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05306978,"threshold_uncertainty_score":0.4828694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1092441340603241,"score_gpt":0.3926725932667632,"score_spread":0.2834284592064391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}