{"id":"W1982381743","doi":"10.1007/s11095-014-1598-6","title":"Dependence of PEI and PAMAM Gene Delivery on Clathrin- and Caveolin-Dependent Trafficking Pathways","year":2014,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institutes of Health; McMaster University","keywords":"Endocytic cycle; Endocytosis; Polyethylenimine; Clathrin; Gene delivery; Internalization; Cell biology; Transfection; Endosome; Caveolin; Biology; Receptor-mediated endocytosis; Pinocytosis; Caveolae; Signal transduction; Intracellular; Biochemistry; Cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002867174,0.0002263996,0.0001775006,0.0001873705,0.0001618546,0.0003347206,0.0002174115,0.000242493,0.001354738],"category_scores_gemma":[0.0005224177,0.000152749,0.0001817349,0.0001666231,0.0002885712,0.0004135993,0.0002744275,0.0003908352,0.0003267705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005420999,"about_ca_system_score_gemma":0.0004002715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008624998,"about_ca_topic_score_gemma":0.001419458,"domain_scores_codex":[0.9997414,0.00005929793,0.00002453333,0.00003306009,0.00008226407,0.00005946555],"domain_scores_gemma":[0.999487,0.0002801099,0.00006564429,0.00005486391,0.0000612263,0.00005109404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002852006,0.00001493994,0.0000913677,0.00003534144,0.000003736784,0.00004323513,0.00001584255,0.00004583914,0.9978086,0.0004281828,0.00002748863,0.001200306],"study_design_scores_gemma":[0.000004716033,0.00005464554,0.001770063,0.000002887902,0.000003626067,0.00007822418,0.000007587415,0.0003491201,0.9970489,0.00004278098,0.0006349107,0.000002430024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897116,0.001755118,0.003182427,0.0001344082,0.00002948611,0.00003072469,0.0003128812,0.00008879309,0.0047545],"genre_scores_gemma":[0.9924339,0.0007296461,0.002557628,0.0000568233,0.00001029314,0.00004167753,0.0004428177,0.00003429173,0.003692915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354738,"threshold_uncertainty_score":0.00453198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1092441340603241,"score_gpt":0.3926725932667632,"score_spread":0.2834284592064391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}