{"id":"W1982429227","doi":"10.1016/j.pain.2012.04.020","title":"An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee","year":2012,"lang":"en","type":"article","venue":"Pain","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":373,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Placebo; Osteoarthritis; WOMAC; Medicine; Fatty acid amide hydrolase; Internal medicine; Anesthesia; Interim analysis; Clinical trial; Antagonist","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003903203,0.002354495,0.004891336,0.0009319449,0.0006331206,0.001047577,0.001305735,0.003129369,0.01001256],"category_scores_gemma":[0.004684281,0.001093229,0.001652732,0.000653905,0.002553704,0.001385091,0.0006194132,0.002228787,0.001388451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007805166,"about_ca_system_score_gemma":0.001702074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00068931,"about_ca_topic_score_gemma":0.001368881,"domain_scores_codex":[0.9974396,0.001567944,0.0001693113,0.0003475408,0.0002008448,0.0002747586],"domain_scores_gemma":[0.9979644,0.000768577,0.0004452079,0.0002209865,0.0001434791,0.0004574531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9864498,0.004576698,0.00007757632,0.0003700158,0.0001799082,0.0000202972,0.00002566832,0.0001670504,0.002050046,0.0001444801,0.0002392102,0.005699272],"study_design_scores_gemma":[0.9675388,0.03177739,0.0001373357,0.00001025373,0.0000540919,0.000006343104,0.000003396346,0.0001112683,0.0001092996,0.00006384765,0.0001824465,0.00000549676],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9475015,0.005547993,0.003057611,0.0013657,0.001607183,0.03462152,0.002179365,0.0002587862,0.003860353],"genre_scores_gemma":[0.9348961,0.003779748,0.007660441,0.002001788,0.001274165,0.04198951,0.001596811,0.00004859343,0.006752877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01001256,"threshold_uncertainty_score":0.03349537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008377225942300962,"score_gpt":0.2668082087929911,"score_spread":0.2584309828506901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}