{"id":"W1982453785","doi":"10.1021/bi200809p","title":"Structural Basis of the Substrate Specificity of Bifunctional Isocitrate Dehydrogenase Kinase/Phosphatase","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Isocitrate dehydrogenase; Bifunctional; Phosphofructokinase 2; Biochemistry; Substrate specificity; Substrate (aquarium); Chemistry; Phosphatase; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001385181,0.0001361714,0.0001534466,0.00001513147,0.00008720154,0.000008325806,0.0002668562,0.0001044915,0.002220573],"category_scores_gemma":[0.00004367314,0.00009503934,0.0001221578,0.0001585557,0.0003000105,0.00006723489,0.0000548032,0.00008773194,0.000009647788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002394602,"about_ca_system_score_gemma":0.00008702317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001362309,"about_ca_topic_score_gemma":0.0000103415,"domain_scores_codex":[0.9990417,0.00002921262,0.0002953584,0.0002295546,0.0002388942,0.0001653282],"domain_scores_gemma":[0.9991737,0.00002078395,0.000253372,0.0003872196,0.0001088713,0.00005602595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009659131,0.00002339103,0.003878552,0.00006219522,0.00001212699,0.000001566045,0.0000790254,0.000008851274,0.9947771,0.0005212671,0.0004716221,0.00006768038],"study_design_scores_gemma":[0.000187868,0.00002280203,0.01839695,0.00001704246,0.00002790039,0.000009325552,0.00009351804,0.00002243953,0.9803962,0.000708946,0.00001901099,0.00009795681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971226,0.0002536066,0.00002876977,0.00001143266,0.0004784095,0.00006586287,0.0003320985,0.00001938269,0.00168784],"genre_scores_gemma":[0.9991997,0.00000422064,0.0005090066,0.00002536211,0.0001052888,0.000003384317,0.00002283447,0.000008576585,0.0001216091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0145184,"threshold_uncertainty_score":0.9986916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126322013495893,"score_gpt":0.2078692218867566,"score_spread":0.1866060017517977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}