{"id":"W1982475294","doi":"10.1021/op900004c","title":"Polymorphic Crystallization and Transformation of the Anti-Viral/HIV Drug Stavudine","year":2009,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Stavudine; Human immunodeficiency virus (HIV); Crystallization; Transformation (genetics); Virology; Drug; Medicine; Pharmacology; Chemistry; Biology; Genetics; Antiretroviral therapy; Viral load; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007836729,0.0001781664,0.0002724654,0.0002654482,0.0003176306,0.00003755645,0.0001751656,0.00006587402,0.0001667863],"category_scores_gemma":[0.0001160718,0.0001182931,0.00003189675,0.0009109672,0.0001070443,0.0002012471,0.00005395445,0.0002399269,0.0000323062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083902,"about_ca_system_score_gemma":0.001045541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002309519,"about_ca_topic_score_gemma":0.00001109629,"domain_scores_codex":[0.9976895,0.00007657726,0.0004500463,0.0002802136,0.001100856,0.0004028479],"domain_scores_gemma":[0.9991136,0.00003545044,0.00008598258,0.0002141287,0.000405935,0.0001449292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001176482,0.004255884,0.131018,0.003824827,0.001012893,0.0001027021,0.1580341,0.00002536352,0.5410811,0.006041785,0.01120499,0.1422219],"study_design_scores_gemma":[0.002884671,0.00009844318,0.1667487,0.0006675634,0.00005286713,0.00005291111,0.001520754,0.0001167013,0.8188214,0.001196091,0.007556701,0.0002831607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778573,0.0004504491,0.0005780369,0.01800904,0.00002626364,0.001035805,0.000003615723,0.00005161752,0.001987887],"genre_scores_gemma":[0.9924833,0.0003956169,0.0007077258,0.0000946523,0.00002211842,0.0000295125,0.00005229335,0.00001869926,0.006196072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2777403,"threshold_uncertainty_score":0.4823851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020710814907196,"score_gpt":0.3078338761570689,"score_spread":0.287626768007997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}