{"id":"W1982498121","doi":"10.1038/ncb1748","title":"TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal","year":2008,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":669,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Howard Hughes Medical Institute","keywords":"SMAD; Cell biology; Embryonic stem cell; Biology; Transcription factor; Mediator; Transcriptional regulation; Stem cell; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002290593,0.0003466128,0.0003881732,0.00008773107,0.0003284762,0.00002091279,0.0002880821,0.001330282,0.00002019871],"category_scores_gemma":[0.00001804404,0.000309745,0.0001447704,0.00009402703,0.0002133972,0.000004320692,0.0001336363,0.0005613407,0.00002611975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002180469,"about_ca_system_score_gemma":0.0001066477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001516774,"about_ca_topic_score_gemma":0.00001997449,"domain_scores_codex":[0.9981616,0.0001744378,0.0002963321,0.0007427127,0.00009396976,0.0005309259],"domain_scores_gemma":[0.9990936,0.00005511655,0.0001643692,0.0004289604,0.00009938551,0.0001585718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006820602,0.00008590829,0.003081053,0.00003356281,0.00005411333,0.00002085755,0.00009520811,0.00002082912,0.9959765,0.0001061297,0.0002336907,0.000223951],"study_design_scores_gemma":[0.001844658,0.0006980336,0.000282735,0.00001278344,0.00004895163,0.00009543288,0.00004686209,0.00006244432,0.950549,0.00017777,0.04573818,0.0004431264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821227,0.01406096,0.00002646799,0.00006801663,0.0003276672,0.0002217579,0.00003913432,0.00007961784,0.003053661],"genre_scores_gemma":[0.9954304,0.0007674199,0.0003845627,0.0004894658,0.0004535594,0.00001498042,0.0002479978,0.00004677686,0.002164888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04550449,"threshold_uncertainty_score":0.9999662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006074772622894578,"score_gpt":0.2188929921620648,"score_spread":0.2128182195391702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}