{"id":"W1982573599","doi":"10.1139/o00-090","title":"Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins","year":2001,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Manitoba Health Research Council","keywords":"Insulin receptor; IRS2; Insulin receptor substrate; GRB10; Phosphotyrosine-binding domain; Insulin-like growth factor 1 receptor; Insulin; Biology; Tyrosine phosphorylation; SH2 domain; IRS1; Tyrosine kinase; Receptor tyrosine kinase; Insulin-like growth factor; Cell biology; Phosphorylation; Signal transduction; Receptor; Endocrinology; Biochemistry; Growth factor; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002205755,0.0002415258,0.0001992662,0.00002815859,0.0003100918,0.00002869725,0.0001817426,0.000369114,0.00008205577],"category_scores_gemma":[0.0001401578,0.0001609403,0.00006527411,0.0001578703,0.0004576728,0.000007089842,0.0001233509,0.00017445,0.000001992324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001574044,"about_ca_system_score_gemma":0.00005605328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004647457,"about_ca_topic_score_gemma":0.000004180622,"domain_scores_codex":[0.9987925,0.0001232022,0.0003294896,0.0004216642,0.00008637035,0.0002467161],"domain_scores_gemma":[0.9991816,0.00004229127,0.0002456034,0.0003026207,0.000143272,0.00008460406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002223185,0.00006499585,0.001899653,0.00004286094,0.00004585224,3.832645e-7,0.00007206866,0.000008333814,0.994966,0.00002802372,0.00009122054,0.002558309],"study_design_scores_gemma":[0.001107609,0.0002136195,0.002328078,0.00002465893,0.00001658085,0.000006097221,0.00006773169,0.00008803866,0.9888541,0.00005757084,0.007025548,0.0002104428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954876,0.003159873,0.0002489264,0.0003130463,0.00006287825,0.0004239434,0.0001438129,0.00001793589,0.0001419435],"genre_scores_gemma":[0.9983046,0.0004913677,0.0001616833,0.0001241443,0.0001594723,0.00003498493,0.0003694953,0.00001943421,0.0003348045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006934327,"threshold_uncertainty_score":0.6562957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01552019961237813,"score_gpt":0.2402157313791257,"score_spread":0.2246955317667476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}