{"id":"W1982573599","doi":"10.1139/o00-090","title":"Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins","year":2001,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Manitoba Health Research Council","keywords":"Insulin receptor; IRS2; Insulin receptor substrate; GRB10; Phosphotyrosine-binding domain; Insulin-like growth factor 1 receptor; Insulin; Biology; Tyrosine phosphorylation; SH2 domain; IRS1; Tyrosine kinase; Receptor tyrosine kinase; Insulin-like growth factor; Cell biology; Phosphorylation; Signal transduction; Receptor; Endocrinology; Biochemistry; Growth factor; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327393,0.0005024275,0.0003197613,0.0002776601,0.0001505027,0.0003259447,0.0002003091,0.0002628511,0.002360623],"category_scores_gemma":[0.0001159473,0.0002413745,0.0003269223,0.0003645002,0.0001692112,0.0001365001,0.00023074,0.0004551248,0.0007838667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004157241,"about_ca_system_score_gemma":0.0001859779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008974616,"about_ca_topic_score_gemma":0.001498156,"domain_scores_codex":[0.9997979,0.0000348732,0.00001733208,0.00004727982,0.00005414211,0.00004856749],"domain_scores_gemma":[0.9999393,0.00001378322,0.0000128023,0.00000988355,0.000005575399,0.00001862989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007735114,0.00002588926,0.0001812951,0.00001671192,0.000006462139,0.00003622061,0.000003996763,0.00001703614,0.9992368,0.00002291702,0.00002063442,0.0003546667],"study_design_scores_gemma":[0.00002675792,0.0002774335,0.01130862,0.00000563596,0.00002608916,0.0002619338,0.00002053092,0.0005691921,0.9851716,0.00002131412,0.002305952,0.00000501092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994636,0.002025224,0.00145217,0.00008212897,0.00003704382,0.00002124628,0.0004580675,0.00006769198,0.001220456],"genre_scores_gemma":[0.9871738,0.00192618,0.003325806,0.0001044609,0.00001848526,0.00005230803,0.002513372,0.00003682246,0.004848818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002360623,"threshold_uncertainty_score":0.007897019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01552019961237813,"score_gpt":0.2402157313791257,"score_spread":0.2246955317667476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}