{"id":"W1982596096","doi":"10.1074/jbc.m109.060178","title":"Suppression of p38 MAPK and JNK via Akt-mediated Inhibition of Apoptosis Signal-regulating Kinase 1 Constitutes a Core Component of the β-Cell Pro-survival Effects of Glucose-dependent Insulinotropic Polypeptide","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Protein kinase B; Cell biology; Biology; Signal transduction; MAPK/ERK pathway; Apoptosis; p38 mitogen-activated protein kinases; Kinase; Protein kinase A; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002080966,0.0001357618,0.0006259292,0.00003672811,0.0000241099,0.000002247776,0.00007347993,0.0001673664,0.00004367642],"category_scores_gemma":[0.0005954482,0.00007565497,0.0001661313,0.0001155901,0.0002851753,0.00002750287,0.00004300747,0.0002121032,1.610635e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002675647,"about_ca_system_score_gemma":0.00006239417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007288419,"about_ca_topic_score_gemma":5.154785e-8,"domain_scores_codex":[0.9986476,0.00006417007,0.0007413141,0.000114563,0.0003128575,0.0001195315],"domain_scores_gemma":[0.9981095,0.0004039851,0.001026559,0.0001260541,0.0002312632,0.0001025966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006508045,0.0006029702,0.03386471,0.0007432979,0.00004775233,0.000005177748,0.00003697689,0.00001522404,0.9635815,0.000004881862,0.00002058874,0.0004261243],"study_design_scores_gemma":[0.002851033,0.0009275278,0.04842636,0.001234915,0.0001260383,0.00002429687,0.00008231889,0.0001019429,0.946075,0.00008605575,0.000003422564,0.00006104774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985173,0.0008395119,0.00009309533,0.00009190183,0.00005715452,0.0001726069,0.00001578277,0.000005759848,0.0002069401],"genre_scores_gemma":[0.9992614,0.00008142461,0.0005345594,0.00003782222,0.00005668555,0.000001218352,0.00001220667,0.000003839873,0.00001086863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01750645,"threshold_uncertainty_score":0.308512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01574852130944964,"score_gpt":0.2326729019830037,"score_spread":0.216924380673554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}