{"id":"W1982615776","doi":"10.1074/jbc.m114.616185","title":"Efflux by Small Multidrug Resistance Proteins Is Inhibited by Membrane-interactive Helix-stapled Peptides","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Efflux; Multiple drug resistance; Chemistry; Helix (gastropod); Biochemistry; Biology; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001170837,0.0002766417,0.0002336287,0.0000744087,0.00007608702,0.0002601621,0.0001689919,0.0001827175,0.0006805781],"category_scores_gemma":[0.0001268518,0.0001101476,0.0002124279,0.0000821943,0.0001541348,0.0001685365,0.0001642575,0.0003456889,0.0003318758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001679992,"about_ca_system_score_gemma":0.0001077984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002096847,"about_ca_topic_score_gemma":0.0002539905,"domain_scores_codex":[0.9998803,0.00003214448,0.00001375415,0.00001459931,0.00003468492,0.00002451382],"domain_scores_gemma":[0.9999115,0.0000169908,0.00003460911,0.000006994216,0.00000816196,0.00002183965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003657968,0.00001183056,0.00005655875,0.000008378495,0.000002636219,0.00001798232,0.000003757852,0.00006058952,0.9994671,0.00002283254,0.000007517142,0.0003043631],"study_design_scores_gemma":[0.00001910361,0.0002516102,0.001067312,0.000002358367,0.000006368782,0.0001042295,0.000007325454,0.0006229434,0.9969867,0.00001376251,0.0009142609,0.000003864217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983381,0.0003317498,0.000772391,0.00002644043,0.00000612747,0.000008956466,0.00004985807,0.00002889187,0.0004375259],"genre_scores_gemma":[0.9971647,0.000285406,0.001590508,0.0000313606,0.000005609191,0.00001367049,0.000202059,0.00001381624,0.000692953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006805781,"threshold_uncertainty_score":0.002276719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007651915025692275,"score_gpt":0.2218867532340058,"score_spread":0.2142348382083135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}