{"id":"W1982652177","doi":"10.1523/jneurosci.5103-08.2009","title":"ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood–Brain Barrier for Aβ<sub>1–40</sub>Peptides","year":2009,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Institute for Biological Sciences","funders":"National Institute of Neurological Disorders and Stroke; Directorate for Biological Sciences; National Institutes of Health; National Institute on Aging; Shanxi Medical University; Alzheimer Society; Arizona Biomedical Research Commission; Heart and Stroke Foundation of Canada; Pfizer; Arizona Department of Health Services; Michael J. Fox Foundation for Parkinson's Research","keywords":"Cerebral amyloid angiopathy; Abcg2; Blood–brain barrier; Western blot; Microglia; Downregulation and upregulation; Immunohistochemistry; Transporter; Chemistry; Biology; Pharmacology; Endocrinology; Internal medicine; Medicine; Immunology; Central nervous system; ATP-binding cassette transporter; Inflammation; Biochemistry; Gene; Dementia; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008487051,0.0003084421,0.000349909,0.0006096273,0.000319442,0.0003904732,0.00009989287,0.000409246,0.001852904],"category_scores_gemma":[0.0001296997,0.0001529694,0.0002106401,0.0006789005,0.0002470243,0.0001638595,0.0001436667,0.0003302692,0.0004068398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474657,"about_ca_system_score_gemma":0.0001414963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001030918,"about_ca_topic_score_gemma":0.0009211014,"domain_scores_codex":[0.9998927,0.00001130246,0.000008939618,0.00002525885,0.00003491874,0.00002687681],"domain_scores_gemma":[0.9998965,0.00000984546,0.00003861868,0.000006941297,0.0000260952,0.0000219579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009408495,0.00008434227,0.0249096,0.0001679037,0.00008137336,0.002465456,0.0001059481,0.0000415225,0.9656649,0.0001729087,0.0005743495,0.004790909],"study_design_scores_gemma":[0.0001040593,0.0003976345,0.7884703,0.00003890648,0.0002840607,0.01102418,0.0004144636,0.001070587,0.1863313,0.0005939367,0.01124589,0.0000245926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948577,0.002416442,0.0005954467,0.0001746566,0.00003752901,0.00001851289,0.0006543874,0.00007762203,0.001167753],"genre_scores_gemma":[0.9940708,0.001276461,0.0007226671,0.0001389496,0.00004101984,0.00005164632,0.001029207,0.00001769646,0.002651577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001852904,"threshold_uncertainty_score":0.006198585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328471736086708,"score_gpt":0.2553034459777337,"score_spread":0.2420187286168667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}