{"id":"W1982653993","doi":"10.1021/bi100939a","title":"The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":279,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Amyloid (mycology); Chemistry; Islet; Fibril; Amylin; Thioflavin; Biochemistry; Amyloid disease; P3 peptide; In vitro; Protein aggregation; Biophysics; Amyloid precursor protein; Amyloid fibril; Amyloid β; Alzheimer's disease; Biology; Insulin; Endocrinology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008389398,0.0003771154,0.0002295275,0.0002320476,0.0001170425,0.0001916525,0.0001909808,0.0002381745,0.0006443258],"category_scores_gemma":[0.00008762549,0.00009872044,0.0003496936,0.0001436148,0.0001353356,0.0001266649,0.0001380949,0.0004218103,0.0002526076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001512936,"about_ca_system_score_gemma":0.0002082066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001253631,"about_ca_topic_score_gemma":0.001336147,"domain_scores_codex":[0.9999325,0.00001246034,0.000009224533,0.000009827464,0.00001578335,0.00002025585],"domain_scores_gemma":[0.9999406,0.00001155567,0.00001371856,0.00001107713,0.000008729903,0.00001426354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001647255,0.00005320951,0.00007121775,0.00002679201,0.000007413024,0.00002511204,0.000008224437,0.00004832631,0.9986867,0.0000152175,0.00002759049,0.000865445],"study_design_scores_gemma":[0.0000213579,0.0005210536,0.002359439,0.00000463649,0.00001814501,0.00008840015,0.00001007167,0.0003212059,0.9957712,0.00001745228,0.0008639095,0.000003042442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994146,0.002695636,0.001558355,0.0001017653,0.00004660432,0.00002129572,0.0002729023,0.0001228435,0.001034661],"genre_scores_gemma":[0.9950857,0.001470802,0.001083165,0.0001010607,0.00001496554,0.00002240231,0.0006061267,0.00002181073,0.001593906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253631,"threshold_uncertainty_score":0.002492607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008662094389906339,"score_gpt":0.2483591264224634,"score_spread":0.2396970320325571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}