{"id":"W1982653993","doi":"10.1021/bi100939a","title":"The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":279,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Amyloid (mycology); Chemistry; Islet; Fibril; Amylin; Thioflavin; Biochemistry; Amyloid disease; P3 peptide; In vitro; Protein aggregation; Biophysics; Amyloid precursor protein; Amyloid fibril; Amyloid β; Alzheimer's disease; Biology; Insulin; Endocrinology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002351038,0.0004649414,0.0003624104,0.00004875692,0.0005352355,0.0002035196,0.000242961,0.0003165754,0.00002847368],"category_scores_gemma":[0.000239736,0.000320392,0.0001559917,0.0002313767,0.0002919032,0.0001991216,0.0001633692,0.0006561382,0.00007376994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001091931,"about_ca_system_score_gemma":0.0002144119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007244362,"about_ca_topic_score_gemma":0.00002789495,"domain_scores_codex":[0.9975859,0.00005229738,0.0004263793,0.0005838668,0.0006172549,0.0007342851],"domain_scores_gemma":[0.9981644,0.00008710986,0.0002238219,0.0006791452,0.0001663437,0.0006791625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002900227,0.0002332769,0.0004040596,0.0002005828,0.0005885657,0.00002394985,0.00009939231,2.20362e-7,0.9914196,0.00000379595,0.003900178,0.002836403],"study_design_scores_gemma":[0.00181641,0.0001482527,0.000348128,0.0001698504,0.0001157818,0.00005341256,0.0001418024,0.0001760898,0.9953241,0.00004505336,0.001326743,0.0003344037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930558,0.003024619,0.000006307994,0.001040203,0.00008404434,0.001294881,0.0001757311,0.0001740652,0.001144333],"genre_scores_gemma":[0.9975644,0.0006161336,0.0001726332,0.0001600962,0.0002457619,0.0001589785,0.0004267707,0.00005318835,0.0006019998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004508622,"threshold_uncertainty_score":0.9999248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008662094389906339,"score_gpt":0.2483591264224634,"score_spread":0.2396970320325571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}