{"id":"W1982667029","doi":"10.1371/journal.ppat.1000233","title":"FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling","year":2008,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; McMaster University; McMaster University Medical Centre","funders":"Université Paris-Est Créteil Val-de-Marne; Canadian Institutes of Health Research; Hospital for Sick Children; Sick Kids Foundation","keywords":"Fimbria; Bacterial adhesin; Interferon; Innate immune system; Microbiology; Inducer; Biology; Antimicrobial; TLR4; Neisseria; Escherichia coli; Cell biology; Immunology; Gene; Signal transduction; Bacteria; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053384,0.00029901,0.0001839604,0.000184213,0.0001037903,0.0001804618,0.0001111185,0.0002889657,0.001001116],"category_scores_gemma":[0.00009916114,0.00009857144,0.0001851246,0.00009095632,0.0001808775,0.0001209344,0.0002562978,0.0005502504,0.0002186403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001882573,"about_ca_system_score_gemma":0.0001063732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004602243,"about_ca_topic_score_gemma":0.0004718279,"domain_scores_codex":[0.9998796,0.00001737712,0.000007301651,0.00001958165,0.00004136817,0.00003476917],"domain_scores_gemma":[0.9999181,0.0000118282,0.00003030518,0.000008984151,0.000009773245,0.00002104936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002793203,0.00001106596,0.000189106,0.00001459,0.000001657462,0.00002690674,0.000003171158,0.000007681535,0.9991167,0.00002271891,0.00001854771,0.0005598006],"study_design_scores_gemma":[0.0000111287,0.0004073835,0.02078581,0.000009294637,0.00001285328,0.0005510074,0.00002510749,0.0004218748,0.9756415,0.00005338355,0.002076554,0.000004015234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954001,0.00135518,0.001938724,0.0001185617,0.0000212592,0.0000220029,0.0003380674,0.00005690825,0.0007491806],"genre_scores_gemma":[0.9929056,0.0008753068,0.002753719,0.00007236421,0.00001303158,0.00002280239,0.0006473099,0.000010518,0.002699334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001116,"threshold_uncertainty_score":0.003349066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04135053944872327,"score_gpt":0.2474761235278096,"score_spread":0.2061255840790863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}