{"id":"W1982667029","doi":"10.1371/journal.ppat.1000233","title":"FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling","year":2008,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; McMaster University; McMaster University Medical Centre","funders":"Université Paris-Est Créteil Val-de-Marne; Canadian Institutes of Health Research; Hospital for Sick Children; Sick Kids Foundation","keywords":"Fimbria; Bacterial adhesin; Interferon; Innate immune system; Microbiology; Inducer; Biology; Antimicrobial; TLR4; Neisseria; Escherichia coli; Cell biology; Immunology; Gene; Signal transduction; Bacteria; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002448632,0.0001642605,0.000365349,0.0002130824,0.000107631,0.000004953748,0.0001337031,0.0002574745,0.0002075852],"category_scores_gemma":[0.0003812152,0.0001499726,0.00005978144,0.0002687876,0.0001843714,0.00009815481,0.00009867426,0.00018732,0.00007749419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001928292,"about_ca_system_score_gemma":0.0001542957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004046699,"about_ca_topic_score_gemma":0.000004978335,"domain_scores_codex":[0.9987094,0.0003030211,0.0004796196,0.0002268325,0.00005211378,0.0002289922],"domain_scores_gemma":[0.9989563,0.0001631178,0.0002418988,0.0002372691,0.0003851798,0.000016249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003294454,0.0001211606,0.002741272,0.00006287518,0.0001843622,0.000009095129,0.002486165,0.000004943176,0.9898466,0.00002670577,0.0006371954,0.0005851508],"study_design_scores_gemma":[0.0005990922,0.000761422,0.01205145,0.0001886726,0.00007155856,0.00006384525,0.0001118276,0.00001989036,0.9853123,0.00001399941,0.0006551752,0.0001507489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976129,0.001585437,0.00001059292,0.0001630818,0.0002170865,0.0001790532,0.00004659498,0.00002528012,0.0001599813],"genre_scores_gemma":[0.9981449,0.0008854257,0.0001322604,0.00006904899,0.00002057385,0.000002866499,0.00005312068,0.0000196928,0.000672149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009310182,"threshold_uncertainty_score":0.6115706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04135053944872327,"score_gpt":0.2474761235278096,"score_spread":0.2061255840790863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}