{"id":"W1982682419","doi":"10.1074/jbc.m114.626861","title":"LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Structural Genomics Consortium","funders":"Canadian Institutes of Health Research; Office of Science; Ontario Genomics; National Institutes of Health; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Wellcome Trust; Genome Canada; GlaxoSmithKline; Pfizer; Eli Lilly and Company; Ministero dello Sviluppo Economico; Argonne National Laboratory; U.S. Department of Energy","keywords":"Methyltransferase; Histone methyltransferase; Histone; Lysine; Chromatin; Biology; Chemistry; Methylation; Biochemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001127,0.0003328783,0.0002746832,0.0001761257,0.0001228208,0.000186202,0.0002438177,0.0002687748,0.0007041888],"category_scores_gemma":[0.00006551397,0.0001257795,0.0002310848,0.0001227367,0.000156124,0.0001289531,0.0001425877,0.0004628989,0.0003512353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002870828,"about_ca_system_score_gemma":0.0002083967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000646361,"about_ca_topic_score_gemma":0.001862752,"domain_scores_codex":[0.9999188,0.00001291091,0.000008775522,0.00001338508,0.00002224574,0.00002373932],"domain_scores_gemma":[0.9999573,0.00001097766,0.000007788109,0.000004649352,0.000004877021,0.00001444978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001230402,0.00004766226,0.0001639626,0.00005193086,0.00001129523,0.00004945519,0.00000872519,0.0001049188,0.9966369,0.00006469795,0.0001919313,0.002545405],"study_design_scores_gemma":[0.00006600039,0.0007075523,0.002431699,0.000004715299,0.00002315069,0.0001991584,0.00001182265,0.0007525699,0.9914953,0.00002340235,0.004279471,0.000005328591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815819,0.009013843,0.004324953,0.0002704706,0.00006897601,0.00007426742,0.0007689927,0.0002533555,0.003643247],"genre_scores_gemma":[0.9848415,0.004784385,0.003880639,0.0001955019,0.00002247173,0.00009195519,0.001936221,0.00002239358,0.004225026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007041888,"threshold_uncertainty_score":0.002355754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215760525242166,"score_gpt":0.2557455950775571,"score_spread":0.2341695425533405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}