{"id":"W1982682419","doi":"10.1074/jbc.m114.626861","title":"LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Structural Genomics Consortium","funders":"Canadian Institutes of Health Research; Office of Science; Ontario Genomics; National Institutes of Health; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Wellcome Trust; Genome Canada; GlaxoSmithKline; Pfizer; Eli Lilly and Company; Ministero dello Sviluppo Economico; Argonne National Laboratory; U.S. Department of Energy","keywords":"Methyltransferase; Histone methyltransferase; Histone; Lysine; Chromatin; Biology; Chemistry; Methylation; Biochemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003622397,0.0001507995,0.0002800046,0.0000247424,0.0000265376,0.00001052114,0.0001239196,0.0002606664,0.000009607279],"category_scores_gemma":[0.00032759,0.0001104015,0.0001215539,0.00009308168,0.0001279614,0.000005518687,0.00005440039,0.0001902421,4.102619e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002017593,"about_ca_system_score_gemma":0.0001188423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003845813,"about_ca_topic_score_gemma":3.83676e-7,"domain_scores_codex":[0.999012,0.00007556761,0.0003994506,0.0001968748,0.0001624036,0.0001536897],"domain_scores_gemma":[0.9989204,0.00002178013,0.0003101576,0.0001207284,0.0004324703,0.0001944243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005035824,0.0001579812,0.001292646,0.00003120484,0.00004901113,0.000007679241,0.00003282201,0.00002798154,0.9960856,0.000001652336,0.00004647104,0.001763379],"study_design_scores_gemma":[0.001008945,0.001092348,0.001117351,0.00001995237,0.0000259132,0.0000252032,0.0001098867,0.000007695222,0.9945424,0.0003448708,0.001574546,0.0001309076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931954,0.003798094,0.001750998,0.00008350836,0.00004023637,0.00009695211,0.000018959,0.000002858069,0.001012962],"genre_scores_gemma":[0.9973536,0.0004367418,0.001779603,0.00002088085,0.000280382,0.000003445452,0.00001872256,0.000009502322,0.00009708117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00415821,"threshold_uncertainty_score":0.4502041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215760525242166,"score_gpt":0.2557455950775571,"score_spread":0.2341695425533405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}