{"id":"W1982694875","doi":"10.1371/journal.pbio.1001305","title":"A Novel 3-Hydroxysteroid Dehydrogenase That Regulates Reproductive Development and Longevity","year":2012,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institute on Aging; Max-Planck-Gesellschaft; Bundesministerium für Bildung und Forschung; Natural Sciences and Engineering Research Council of Canada; Ellison Medical Foundation","keywords":"Longevity; Biology; Nuclear receptor; Hydroxysteroid dehydrogenase; Hydroxysteroid Dehydrogenases; Dehydrogenase; Caenorhabditis elegans; Hydroxysteroid; Cell biology; Genetics; Transcription factor; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001995472,0.000113614,0.000246591,0.00006603989,0.00006412183,0.00000368757,0.00002740355,0.0001069753,0.0000373928],"category_scores_gemma":[0.0001296662,0.00008188353,0.00002685657,0.00005705646,0.00009534167,0.00006154647,0.00005601811,0.00008257732,0.00004701265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004136232,"about_ca_system_score_gemma":0.00003269588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008338249,"about_ca_topic_score_gemma":0.000004229903,"domain_scores_codex":[0.9992547,0.00002771472,0.0001432492,0.0002554829,0.00008370074,0.0002351506],"domain_scores_gemma":[0.9994909,0.00003873593,0.00005340644,0.000199159,0.00005553181,0.0001622818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001668667,0.0003694954,0.1120283,0.00003345781,0.000141089,0.000006282767,0.0008637944,1.534137e-7,0.8734225,0.0005074128,0.00008053269,0.01238017],"study_design_scores_gemma":[0.000922752,0.0001298672,0.4085746,0.00004410045,0.00007805682,0.0005656756,0.00008113965,0.0001402424,0.5605017,0.00006656033,0.02873117,0.0001641733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959605,0.002169509,0.0001067182,0.0009633061,0.00006759234,0.0002179418,0.000002439913,0.00004349502,0.0004685331],"genre_scores_gemma":[0.9957408,0.00003201067,0.003223017,0.0004313674,0.0001708314,0.00001289035,0.00003378504,0.00001155582,0.0003437707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3129208,"threshold_uncertainty_score":0.3339113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07935396348884328,"score_gpt":0.2810003868867986,"score_spread":0.2016464233979554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}