{"id":"W1982726068","doi":"10.1016/j.diff.2014.12.003","title":"Optimized osteogenic differentiation protocol from R1 mouse embryonic stem cells in vitro","year":2015,"lang":"en","type":"article","venue":"Differentiation","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Retinoic acid; Biology; Embryonic stem cell; Cell biology; In vitro; Adipogenesis; Cellular differentiation; Stem cell; Lineage (genetic); Dexamethasone; Cell culture; Mesenchymal stem cell; Endocrinology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422551,0.0002498944,0.0002567992,0.0001487406,0.0000520875,0.00008988983,0.0002975047,0.0002541543,0.00004310961],"category_scores_gemma":[0.00003280288,0.0002402708,0.000118026,0.0001506195,0.00002920027,0.0000190122,0.0001957411,0.0001690931,0.00009298844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001352097,"about_ca_system_score_gemma":0.0001125095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007710695,"about_ca_topic_score_gemma":0.00004775337,"domain_scores_codex":[0.9978705,0.0003412851,0.0003861268,0.0005620197,0.0004466807,0.0003933608],"domain_scores_gemma":[0.9989752,0.00002181549,0.0001894559,0.0004954914,0.0001458401,0.000172177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009250588,0.0002200427,0.001582709,0.00002870722,0.00004772057,0.00000180605,0.00008153016,0.0003928629,0.9949089,0.000003370803,0.0004219919,0.00138536],"study_design_scores_gemma":[0.004950534,0.0001268505,0.00456639,0.00001408904,0.00001850488,7.315679e-7,0.00006550776,0.007362851,0.9817833,0.00004134539,0.0008082181,0.0002616629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790753,0.00005040564,0.005477994,0.00006219911,0.0001782797,0.01488612,0.00008123824,0.00003468969,0.0001538347],"genre_scores_gemma":[0.983952,0.00001533577,0.0004155268,0.0000352873,0.0001606608,0.01217317,0.001404912,0.00004757128,0.001795552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01312552,"threshold_uncertainty_score":0.9797961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02183395940061452,"score_gpt":0.2688698606883098,"score_spread":0.2470359012876953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}