{"id":"W1982827319","doi":"10.1002/cam4.93","title":"Reduction in serum clusterin is a potential therapeutic biomarker in patients with castration‐resistant prostate cancer treated with custirsen","year":2013,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Juravinski Cancer Centre; Université de Montréal","funders":"Canadian Urological Oncology Group; Sanofi","keywords":"Clusterin; Medicine; Docetaxel; Prostate cancer; Internal medicine; Oncology; Mitoxantrone; Chemotherapy; Population; Hazard ratio; Gastroenterology; Urology; Cancer; Confidence interval; Apoptosis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009707743,0.0002768754,0.0004604085,0.000314717,0.00003823896,0.00001119884,0.00007323478,0.00009822144,0.001620365],"category_scores_gemma":[0.0000113422,0.0001778366,0.00002273388,0.0006231189,0.0002930948,0.0001474202,0.00002509668,0.0002109816,0.000009333303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005053205,"about_ca_system_score_gemma":0.0002513608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005952863,"about_ca_topic_score_gemma":0.001471621,"domain_scores_codex":[0.998243,0.00007568254,0.0004186487,0.0004776119,0.0003750532,0.0004100344],"domain_scores_gemma":[0.999085,0.00001303626,0.0001548296,0.0003218999,0.0002524318,0.0001728148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01055085,0.00037267,0.9392747,0.0003547074,0.000170431,0.0002170513,0.002464256,0.0002612062,0.01983016,0.000001601521,0.001203534,0.02529887],"study_design_scores_gemma":[0.01452557,0.001095077,0.9809659,0.001218011,0.000199658,0.00004111352,0.0005722645,0.0007214541,0.0002901735,0.00001055516,0.0001574221,0.0002028308],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897698,0.0007598329,0.00001359184,0.006981986,0.0002009451,0.00197847,0.00004736524,0.00004072455,0.0002073149],"genre_scores_gemma":[0.9971656,0.0001371843,0.00005841091,0.0007772835,0.0001159971,0.0008264427,0.00007451465,0.0000495626,0.0007949888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04169122,"threshold_uncertainty_score":0.9992923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01446286539635256,"score_gpt":0.2799901624254989,"score_spread":0.2655272970291463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}