{"id":"W1982830211","doi":"10.1089/jir.2014.0209","title":"The Mechanism of Interferon Refractoriness During Hepatitis C Virus Infection and Its Reversal with a Peroxisome Proliferator-Activated Receptor α Agonist","year":2015,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta; National Medical Research Council; Medical Research Council; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada","keywords":"SOCS3; Agonist; Interferon; Peroxisome proliferator-activated receptor; Biology; Signal transduction; Endocrinology; Rosiglitazone; Receptor; Internal medicine; Immunology; Cell biology; STAT3; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003263113,0.0002794528,0.0003637938,0.000227475,0.0001299361,0.0002595784,0.0002084834,0.000303728,0.0005528023],"category_scores_gemma":[0.0001928607,0.0001684244,0.00032134,0.0001260835,0.0003200269,0.0002674474,0.0002044209,0.0004723278,0.0002222766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002054574,"about_ca_system_score_gemma":0.0001412332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000201409,"about_ca_topic_score_gemma":0.0002523486,"domain_scores_codex":[0.9998759,0.00004507601,0.0000119085,0.00001445196,0.00002017739,0.00003254112],"domain_scores_gemma":[0.9999002,0.00001570904,0.00003782675,0.00001630453,0.000007710732,0.00002219959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00261574,0.0001103183,0.006662066,0.00009300234,0.00002542395,0.001081016,0.00007799666,0.000111299,0.9758227,0.0003045315,0.00009005864,0.01300582],"study_design_scores_gemma":[0.0006003825,0.01331128,0.2853787,0.00005420418,0.000228903,0.01483339,0.000354516,0.002814107,0.6762084,0.0009082527,0.005265203,0.00004271121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954606,0.00310026,0.0006964368,0.0001054985,0.00001300426,0.00002500835,0.00002764679,0.000023984,0.0005475116],"genre_scores_gemma":[0.9985967,0.0006816367,0.0002199148,0.00004438664,0.0000126377,0.0000158744,0.00004981636,0.000003431348,0.0003755264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005528023,"threshold_uncertainty_score":0.001849294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760672414269514,"score_gpt":0.3145241688134293,"score_spread":0.2669174446707341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}