{"id":"W1982832616","doi":"10.1080/01635581.2012.711418","title":"Vitamin D Intake Is Negatively Associated with Promoter Methylation of the Wnt Antagonist Gene<i>DKK1</i>in a Large Group of Colorectal Cancer Patients","year":2012,"lang":"en","type":"article","venue":"Nutrition and Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Ontario Institute for Cancer Research; Memorial University of Newfoundland; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University Health Network; University of Toronto; Cancer Care Ontario","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"DNA methylation; Epigenetics; DKK1; Wnt signaling pathway; Body mass index; Colorectal cancer; Internal medicine; Methylation; Medicine; Endocrinology; MTRR; Vitamin D and neurology; Cancer; Biology; Physiology; Oncology; Gene; Genetics; Methylenetetrahydrofolate reductase; Allele; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341704,0.00008488503,0.0001180165,0.00002679187,0.00003946758,0.000005021927,0.00004320566,0.00009615999,0.00002508857],"category_scores_gemma":[0.00001657249,0.00005790539,0.00003518274,0.0001242177,0.00005849834,0.00000859996,0.00002598948,0.00005012456,7.977073e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003071978,"about_ca_system_score_gemma":0.00002780999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009054411,"about_ca_topic_score_gemma":0.000716,"domain_scores_codex":[0.9993669,0.00007192844,0.0001728778,0.000128895,0.0001257349,0.0001337115],"domain_scores_gemma":[0.9995978,0.000008206228,0.0001751823,0.00006268218,0.0001258294,0.00003026701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000098628,0.0003727078,0.4171115,0.00003988007,0.00003173712,2.936042e-8,0.0003583122,0.000002075393,0.5807282,0.00001537027,0.00003455297,0.001207006],"study_design_scores_gemma":[0.001058521,0.0001205615,0.4501649,0.00005258898,0.00001501202,5.832089e-8,0.0000234258,0.00001815184,0.5474745,0.00002517302,0.0009917079,0.0000553906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969024,0.002236896,0.000075711,0.0000726267,0.00007555409,0.0003073768,0.0002889608,0.000001728864,0.00003875651],"genre_scores_gemma":[0.9987001,0.0008893525,0.00007567294,0.00006673564,0.00004141618,0.00008758262,0.00009549459,0.0000097913,0.00003379636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03325367,"threshold_uncertainty_score":0.2361313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009419294720186312,"score_gpt":0.2543333297323359,"score_spread":0.2449140350121495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}