{"id":"W1982857430","doi":"10.1136/bmj.330.7482.79","title":"Recent developments in gene transfer: risk and ethics","year":2005,"lang":"en","type":"review","venue":"BMJ","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Genetic enhancement; Clinical trial; Gene transfer; Adenosine deaminase deficiency; Haemophilia; Vector (molecular biology); Medicine; Gene; Transplantation; Immunology; Oncology; Biology; Genetics; Internal medicine; Surgery; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05305206,0.0006190785,0.001083707,0.001251888,0.002108327,0.008122142,0.002265885,0.0137524,0.007336545],"category_scores_gemma":[0.08433311,0.0004610909,0.0006636626,0.001913006,0.0213824,0.008842907,0.003342438,0.01677334,0.002456025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006048964,"about_ca_system_score_gemma":0.00683431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001548311,"about_ca_topic_score_gemma":0.001467397,"domain_scores_codex":[0.9723069,0.01582407,0.001583155,0.002204711,0.0074564,0.0006247365],"domain_scores_gemma":[0.8854386,0.09196794,0.004843333,0.006030103,0.008186639,0.003533358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001289377,0.0001131315,0.001029645,0.001371168,0.00003339789,0.0006673337,0.001770828,0.0007710078,0.0007566564,0.5857244,0.1319018,0.2757318],"study_design_scores_gemma":[0.00003764305,0.0001518355,0.0008921679,0.002641154,0.00002424922,0.002217731,0.0006069281,0.0005270818,0.0005006491,0.2558601,0.7364926,0.0000478956],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.002678258,0.3173076,0.01738472,0.6113797,0.008914297,0.00006754254,0.00008230285,0.0001382709,0.04204733],"genre_scores_gemma":[0.119636,0.3901822,0.03009994,0.3852404,0.05169453,0.0005581056,0.0002184827,0.0002925426,0.02207781],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.05305206,"threshold_uncertainty_score":0.2805694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1059663706545733,"score_gpt":0.4281354649114292,"score_spread":0.3221690942568559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}