{"id":"W1982873906","doi":"10.2174/1568026013395605","title":"Multidrug Efflux in Pseudomonas aeruginosa Components, Mechanisms and Clinical Significance","year":2001,"lang":"en","type":"review","venue":"Current Topics in Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":269,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Cystic Fibrosis Canada; Ministry of Education, Culture, Sports, Science and Technology; Cystic Fibrosis Foundation","keywords":"Efflux; Pseudomonas aeruginosa; Multiple drug resistance; Biology; Periplasmic space; Microbiology; Bacterial outer membrane; Antimicrobial; Antiporter; Antibiotic resistance; Quorum sensing; Homoserine; Drug resistance; Bacteria; Biochemistry; Antibiotics; Genetics; Membrane; Escherichia coli; Gene; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006489041,0.0005390252,0.001388768,0.00006095659,0.00003470418,0.00002405567,0.0005444442,0.0007573973,0.00003684545],"category_scores_gemma":[0.0003658473,0.0004964758,0.0002405557,0.0001864642,0.0003218055,0.000004258239,0.0002655303,0.001098188,0.000006043491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001169627,"about_ca_system_score_gemma":0.0002584861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001388462,"about_ca_topic_score_gemma":0.00001856534,"domain_scores_codex":[0.99683,0.0001877353,0.00124024,0.001001185,0.0002791259,0.0004616602],"domain_scores_gemma":[0.9986418,0.0001007605,0.0003946269,0.0006341111,0.00004124301,0.0001874748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006088959,0.0005434113,0.01205679,0.02151183,0.0001084332,0.0001675205,0.00002376064,6.978289e-7,0.001128337,0.0000725415,0.0007932987,0.9635325],"study_design_scores_gemma":[0.001000196,0.00005232874,0.001065246,0.01221036,0.000153376,0.00009212671,0.00003572123,0.00001605084,0.0002646096,0.00008867156,0.9843926,0.0006286474],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01723067,0.9805822,0.0002216729,0.00002851366,0.0009353159,0.0005294115,0.00003429403,0.00001213902,0.0004257186],"genre_scores_gemma":[0.001321427,0.9959561,0.0005031963,0.00002155634,0.001165472,0.00003444947,0.0005802267,0.00004426045,0.0003733073],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9835994,"threshold_uncertainty_score":0.9997487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05694919784018947,"score_gpt":0.3785586081124495,"score_spread":0.32160941027226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}