{"id":"W1982881757","doi":"10.1038/onc.2011.117","title":"Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; University of British Columbia; Cancer Research Institute","keywords":"Biology; DNMT1; DNA methylation; Cancer research; Methylation; Methyltransferase; DNA methyltransferase; Downregulation and upregulation; Gene knockdown; Cadherin; PI3K/AKT/mTOR pathway; Ovarian carcinoma; Molecular biology; Ovarian cancer; Cell culture; Cell; Signal transduction; Cancer; Gene expression; Cell biology; DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001535581,0.0001718632,0.0002558012,0.0002236849,0.0001778547,0.0002916702,0.0001812139,0.0001285484,0.001260694],"category_scores_gemma":[0.0002131971,0.0001704034,0.0001824077,0.0002172706,0.0002261175,0.0001552899,0.0002043073,0.0004028725,0.0002385392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000242252,"about_ca_system_score_gemma":0.0002733508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001778111,"about_ca_topic_score_gemma":0.002207022,"domain_scores_codex":[0.9998796,0.00002203413,0.00001267389,0.00001600033,0.00003317344,0.0000365495],"domain_scores_gemma":[0.9999043,0.00002962501,0.0000165111,0.00001598369,0.000009587062,0.00002401668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002921166,0.00003255614,0.0005772462,0.00002547263,0.000004626849,0.00007865175,0.00003159704,0.00005645705,0.9974606,0.0001331727,0.00006710166,0.001240248],"study_design_scores_gemma":[0.00003826866,0.000447963,0.01099646,0.000002286256,0.00001555949,0.0002573566,0.00008325128,0.001347802,0.9844619,0.00008047626,0.002264754,0.000003855849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972787,0.0007325553,0.0008188187,0.00008799106,0.00002553492,0.000008212419,0.0001883755,0.00005645457,0.0008032754],"genre_scores_gemma":[0.998265,0.0002298996,0.0002648464,0.0000134367,0.000004395131,0.000008805753,0.0002043664,0.000005976721,0.001003308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001778111,"threshold_uncertainty_score":0.004217446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01583888518463767,"score_gpt":0.2451848451578338,"score_spread":0.2293459599731961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}