{"id":"W1982881757","doi":"10.1038/onc.2011.117","title":"Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; University of British Columbia; Cancer Research Institute","keywords":"Biology; DNMT1; DNA methylation; Cancer research; Methylation; Methyltransferase; DNA methyltransferase; Downregulation and upregulation; Gene knockdown; Cadherin; PI3K/AKT/mTOR pathway; Ovarian carcinoma; Molecular biology; Ovarian cancer; Cell culture; Cell; Signal transduction; Cancer; Gene expression; Cell biology; DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004883411,0.0001541634,0.0001878503,0.00007117406,0.00003833215,0.00001106658,0.000060627,0.0001509266,0.00002783859],"category_scores_gemma":[0.00006543174,0.000152153,0.00004054166,0.0001109376,0.00004829712,0.00001255384,0.00005043947,0.00007180934,8.769471e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001098305,"about_ca_system_score_gemma":0.00003161309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003421248,"about_ca_topic_score_gemma":0.00007921283,"domain_scores_codex":[0.9987869,0.0002109449,0.0003582268,0.0003602103,0.0001199801,0.0001637199],"domain_scores_gemma":[0.9994712,0.00002077531,0.0001312056,0.0002367915,0.00007553567,0.00006452199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001894127,0.0001289684,0.002466139,0.00003544056,0.00001355692,0.000003117042,0.0002926014,0.00001557052,0.9926491,0.00000399351,0.00001370917,0.00418841],"study_design_scores_gemma":[0.0006925571,0.0002841112,0.002499457,0.00004775072,0.00002166952,0.000002881934,0.00004567319,0.00005028028,0.9953499,0.0002294044,0.0006104879,0.0001657743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907303,0.002085407,0.006303087,0.00001478537,0.00005089625,0.0002563916,0.00004227054,0.000008627168,0.0005082034],"genre_scores_gemma":[0.9892954,0.000631748,0.009734198,0.00002693095,0.00004935947,0.00001898933,0.000186794,0.00002601517,0.00003056564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004022635,"threshold_uncertainty_score":0.6204619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01583888518463767,"score_gpt":0.2451848451578338,"score_spread":0.2293459599731961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}