{"id":"W1982942418","doi":"10.1016/j.ijrobp.2004.07.686","title":"Multidrug-resistant hela cells overexpressing MRP1 exhibit sensitivity to cell killing by hyperthermia: Interactions with etoposide","year":2004,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"HeLa; Propidium iodide; Multiple drug resistance; Etoposide; Hyperthermia; Cytotoxicity; Apoptosis; Glutathione; Molecular biology; Cancer cell; Calcein; Medicine; Cancer research; Biology; Programmed cell death; Cell; Biochemistry; Drug resistance; Chemotherapy; In vitro; Cancer; Microbiology; Enzyme; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026943,0.0001992477,0.0002871244,0.0001822512,0.0002182828,0.0002772424,0.0001162755,0.0003007889,0.001915414],"category_scores_gemma":[0.0001803046,0.0002381338,0.0002646249,0.0001774828,0.0001716229,0.0002249876,0.0001476152,0.0004192263,0.0005131667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002456471,"about_ca_system_score_gemma":0.00009529389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00124709,"about_ca_topic_score_gemma":0.00118611,"domain_scores_codex":[0.9998652,0.00003136048,0.00001257328,0.00001514425,0.00003512897,0.0000406349],"domain_scores_gemma":[0.9998859,0.00004217035,0.00001884662,0.0000223704,0.0000141197,0.00001661885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001305571,0.00001416675,0.0001823288,0.00001499194,0.000005908692,0.00006161487,0.00003111615,0.00004745262,0.99901,0.00006083735,0.00007208936,0.0003689388],"study_design_scores_gemma":[0.00001578275,0.0001520165,0.009070693,0.000002715193,0.00001329023,0.0003655196,0.0000471448,0.0005318439,0.9884819,0.00003087329,0.001282411,0.000005875482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966102,0.0007810711,0.0007066138,0.0001741746,0.00002493836,0.00001437885,0.0003270028,0.00003371088,0.001327927],"genre_scores_gemma":[0.9968561,0.0004543532,0.0005860032,0.00004108562,0.000008583454,0.00001716602,0.0004014411,0.00001120671,0.001624165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001915414,"threshold_uncertainty_score":0.006407738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01104774887480859,"score_gpt":0.2863139377456961,"score_spread":0.2752661888708875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}