{"id":"W1982949238","doi":"10.1074/jbc.m600307200","title":"Comparative Peptide Binding Studies of the PABC Domains from the Ubiquitin-protein Isopeptide Ligase HYD and Poly(A)-binding Protein","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal; McGill University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Ubiquitin ligase; Peptide; Isothermal titration calorimetry; Binding domain; Plasma protein binding; Ubiquitin; Binding protein; Poly(A)-binding protein; Peptide sequence; Biochemistry; Protein domain; Biology; Molecular biology; Binding site; Chemistry; Cell biology; RNA-binding protein; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005613149,0.0002415134,0.0004206498,0.00001380819,0.0002223673,0.00003320005,0.0004414654,0.000208501,0.00002680048],"category_scores_gemma":[0.0003816817,0.0001222994,0.0002349203,0.0001059707,0.0005506341,0.000007840562,0.0003220404,0.0003795121,0.000001637379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000304679,"about_ca_system_score_gemma":0.00007105846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002005032,"about_ca_topic_score_gemma":0.000008805088,"domain_scores_codex":[0.9984884,0.0001866024,0.000587712,0.0002569259,0.0002146715,0.0002656972],"domain_scores_gemma":[0.9986481,0.0001282778,0.0007303193,0.0002599344,0.0001584086,0.00007497049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001513114,0.00006369012,0.003138545,0.00002893693,0.0001284071,0.000009641201,0.00009304666,0.0000025519,0.9958391,0.00003445029,0.0003757879,0.0001345062],"study_design_scores_gemma":[0.0005519153,0.0002287966,0.001166637,0.000255384,0.00003232399,0.00005993637,0.001376799,0.000001769141,0.993866,0.0006259631,0.001670168,0.0001643661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932954,0.005106363,0.00002356355,0.0004694755,0.0000441598,0.0002632221,0.0001030238,0.000005492047,0.0006893223],"genre_scores_gemma":[0.9979825,0.0001258699,0.0007348664,0.00007584163,0.0005943755,0.00001773123,0.00001948655,0.00001062521,0.0004386902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004980492,"threshold_uncertainty_score":0.4987223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03879549191769248,"score_gpt":0.2805689328815726,"score_spread":0.2417734409638801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}