{"id":"W1982949238","doi":"10.1074/jbc.m600307200","title":"Comparative Peptide Binding Studies of the PABC Domains from the Ubiquitin-protein Isopeptide Ligase HYD and Poly(A)-binding Protein","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal; McGill University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Ubiquitin ligase; Peptide; Isothermal titration calorimetry; Binding domain; Plasma protein binding; Ubiquitin; Binding protein; Poly(A)-binding protein; Peptide sequence; Biochemistry; Protein domain; Biology; Molecular biology; Binding site; Chemistry; Cell biology; RNA-binding protein; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002687407,0.0004346396,0.0004284834,0.0002582099,0.0002471827,0.000187997,0.0005070125,0.0005108892,0.001048575],"category_scores_gemma":[0.0004739187,0.0001873903,0.0003737989,0.0003027621,0.0002049811,0.0002356907,0.0002142968,0.000798833,0.0003015953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005773943,"about_ca_system_score_gemma":0.0001573957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001466627,"about_ca_topic_score_gemma":0.00118851,"domain_scores_codex":[0.9997028,0.00005832214,0.00001346531,0.00005570442,0.0001051501,0.00006455562],"domain_scores_gemma":[0.9997119,0.0001297546,0.00003102017,0.00001285232,0.00005230744,0.00006212456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002177342,0.0000640351,0.0002414505,0.00006966446,0.00001706402,0.00006190983,0.00002898344,0.0004530558,0.9979299,0.00009716904,0.00006855113,0.0007504643],"study_design_scores_gemma":[0.00002600456,0.0002802642,0.007534925,0.000007723617,0.00002170708,0.0003323649,0.00005196612,0.008843154,0.9811009,0.00007565881,0.001708306,0.00001693386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993834,0.001452586,0.003164188,0.00006963427,0.00001741851,0.00001495482,0.0003395435,0.00003038639,0.001077244],"genre_scores_gemma":[0.992589,0.0005674905,0.003863768,0.0001552554,0.00001127505,0.00003806366,0.001340128,0.00002013119,0.001414895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466627,"threshold_uncertainty_score":0.004189253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03879549191769248,"score_gpt":0.2805689328815726,"score_spread":0.2417734409638801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}